engineered

Science & Nature In a recent breakthrough, Dr. Huo Zhipeng and his student Chen Zuoyang from the Hefei Institutes of Physical Science of the...

Science & Nature Neuroscientists can now make precise genetic tweaks to the neurons that are most affected by brain diseases such as Parkinson’s, Huntington’s...

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Research Briefing Published: 09 March 2023 Nature Biotechnology (2023)Cite this article Subjects Fine-tuning gene expression is crucial for generating quantitative phenotypic changes and crop improvement. Using CRISPR–Cas base editing and prime editing, we engineered upstream open reading frames — eukaryotic translational control elements — in rice to incrementally downregulate translation to predictable and desired levels.

MainNonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease worldwide, with >25% of the global population affected1. NAFLD is a progressive disease. Starting with the accumulation of fat within the liver, hepatic steatosis, it can develop into nonalcoholic steatohepatitis (NASH), eventually resulting in liver failure or cancer. NAFLD risk is associated

MainRespiratory diseases are among the top ten causes of death worldwide. Efforts to develop new therapeutics against respiratory tract infections are growing, especially given the mounting concern about antibiotic-resistant bacteria and the paucity of new antibiotics1. Moreover, antibiotic therapies eliminate beneficial lung microbes and can lead to the persistence of pathogenic, resistant strains2. Approximately 65–80%