Identification

Research Briefing Published: 09 January 2023 Nature Biotechnology (2023)Cite this article 330 Accesses 7 Altmetric Metrics details Subjects Sequencing of proteins is a technically difficult task that typically requires digestion into short peptides before detection and identification. We developed a digestion-free method to chemically unfold and ‘scan’ full-length proteins through a nanopore, producing electrical fingerprints

MainCancer immunotherapies that aim to harness the antitumor activity of T cells have shown impressive clinical results in a subset of patients with cancer, and accumulating evidence suggests that the efficacy of these therapies is driven largely by T cells that recognize cancer neoantigens that result from patient-specific nonsynonymous tumor mutations1. Consequently, there is a