Functional

Science & Nature Cancer stem cells (CSCs) represent a self-renewing population capable of fueling long-term tumor growth. In gastric cancer, the identity of CSC...

Science & Nature Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By...

Science & Nature Diapause is a common seasonal adaptive strategy that regulates annual timing in insects. Very few causal loci underlying diapause variation have...

Science & Nature Heterotrophic bacteria and archaea (“heteroprokaryotes”) drive global carbon cycling, but how to quantitatively organize their functional complexity remains unclear. We generated...

Science & Nature Conserved genomic sequences disrupted in humans may underlie uniquely human phenotypic traits. We identified and characterized 10,032 human-specific conserved deletions (hCONDELs)....

Science & Nature The predicted rates, functional effects, and selection pressure of postzygotic mutations vary throughout the human life cycle...Read MoreAlejandro Byron

News & Views Published: 26 January 2023 Protein engineering Nature Biotechnology (2023)Cite this article 640 Accesses 7 Altmetric Metrics details Subjects Functional proteins with limited homology to natural proteins are designed using a large language model. Directed evolution has proven remarkably successful at finding variants of known proteins with enhanced properties1. Yet designing proteins that

Consciousness is a multidimensional phenomenon, but key dimensions such as awareness and wakefulness have been described conceptually rather than neurobiologically. The post Brain’s Functional Geometry...