Science & Nature

MainDrug-response patterns in individuals with complex disease, such as type 2 diabetes (T2D), are intricate. Multiple organs and confounders are typically involved including comorbidities and polypharmacy1,2. Conversely, treatment with one or more drugs and the associated polypharmacy effects can have considerable impact on the molecular profile of the individual; however, such changes are still largely

MainRadiation therapy (RT) has been shown to improve the outcomes of patients with cancer and provide palliation of related symptoms1. Successful RT is contingent on delivering intended sufficient radiation dose to tumor while sparing surrounding normal tissues2. Achieving such a desired therapeutic ratio, that is, maximizing tumor control while minimizing toxicity, requires that the planned

MainGene expression in animals relies on epigenetic marks such as histone modifications to regulate the accessibility and function of the genome in different cell types1. Large-scale efforts characterizing different histone modifications in a variety of cell populations commonly use chromatin immunoprecipitation followed by sequencing (ChIP–seq)2,3,4,5,6,7,8. Alternative strategies to ChIP–seq based on enzyme tethering (chromatin immunocleavage

Apple Apple has created 15 known gestures for your fingers to use on a Multi-Touch trackpad in order to perform a function. At least a couple of them are undoubtedly already second nature in your daily use, but you may not have had a chance to learn others that might really help you out over

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According to a study recently published in the journal iScience, some commercial earbuds may be as effective as hearing aids in amplifying sound for...

Time travel might seem like nothing more than science fiction, but scientists actually say that isn’t the case at all. Time travel could actually...