Science & Nature

Two neutron stars are on a catastrophic collision course in this illustration. NASAA new tool gives astronomers a split-second view of massive, merging stars. The...

Stan HoraczekSave up to 40% on fitness-friendly Beats Fit Pro, Powerbeats Pro, and Beats Studio Buds, and kick off your renewed year right. The post...

Rally and march from University College London Hospital, Euston Road in solidarity with the nurses strike and the NHS on December 20, 2022. Matthew...

A U.S. cargo craft is being loaded with hardware and sensitive research samples for analysis on Earth before it departs the International Space Station...

Shendure, J. et al. DNA sequencing at 40: past, present and future. Nature 550, 345–353 (2017).Article  CAS  Google Scholar  Ameur, A., Kloosterman, W. P. & Hestand, M. S. Single-molecule sequencing: towards clinical applications. Trends Biotechnol. 37, 72–85 (2019).Article  CAS  Google Scholar  Eid, J. et al. Real-time DNA sequencing from single polymerase molecules. Science 323, 133

2022 saw a 25% drop in new drug approvals and a less predictable regulator. The US Food and Drug Administration (FDA) toughened its stand on Accelerated Approvals and submissions based on China-only data. But it also waved through some drugs despite negative votes or previous rejections, published new plans to speed up access to treatments

MainCytosine base editors (CBEs) are gene-editing enzymes capable of programmably introducing C·G-to-T·A base pair changes in the genomic DNA of living cells. This chemical conversion is achieved through enzyme-mediated hydrolytic deamination of cytosine to uracil, which is interpreted as thymine by DNA polymerases1. To date, CBEs are typically composed of four distinct components: a naturally

MainIn mammalian cells, interphase chromosomes are hierarchically organized into large compartments containing topologically associating domains (TADs) at the sub-megabase scale1,2,3. The genome organization is cell type-specific and largely determined by features in DNA sequence and trans-acting factors that regulate chromatin interactions1,2,3,4,5,6,7. Chromatin looping within TADs restricts enhancer–promoter interactions to regulate cell-type-specific gene expression4,5,8,9. While the