protein

Science & Nature Solanaceae plants produce two major classes of valuable sterol-derived natural products—steroidal glycoalkaloids and steroidal saponins—from a common cholesterol precursor. Attempts to...

Science & Nature A multidisciplinary research team has produced a promising virus-fighting protein using a quick, portable process that could be easily deployed at...

Science & Nature Regulation of phosphorylation on aquaporin underlies the ability of sorghum to tolerate alkaline soils...Read MoreLeigha Block

MainAlphaFold2 has shown unprecedented performance in CASP14, the Critical Assessment of protein Structure Prediction1,2,3, predicting two-thirds of the CASP targets with an approximately 1 Å root-mean-square deviation (r.m.s.d.) from the native backbone path4. This success, together with the reliable metrics provided by AlphaFold2 regarding the predicted accuracy of its models, is a tremendous achievement whose impact

MainSpatially resolved transcriptome sequencing has generated biological insights in the study of cell differentiation and tissue development1,2,3 but does not yet incorporate measurements of large protein panels. Previously, we developed microfluidic deterministic barcoding in tissue (DBiT) for co-mapping of whole transcriptome and a panel of 22 proteins at the cellular level (~10-µm pixel size) using

Protein engineers are drawing on rapidly evolving machine learning tools, deep reservoirs of data, and the structure-predicting firepower of AlphaFold2 to pursue more sophisticated de novo protein designs. On 26 January, Profluent came out of stealth mode with $9 million in seed funding to support the company’s efforts to apply machine learning (ML) to engineer

Credit: Pixabay/CC0 Public Domain Researchers at the National Institutes of Health and their colleagues have found that a toxic protein made by the body called DUX4 may be the cause of two very different rare genetic disorders. For patients who have facioscapulohumeral muscular dystrophy (FSHD), or a rare facial malformation called arhinia, this research discovery

Research Briefing Published: 09 January 2023 Nature Biotechnology (2023)Cite this article 330 Accesses 7 Altmetric Metrics details Subjects Sequencing of proteins is a technically difficult task that typically requires digestion into short peptides before detection and identification. We developed a digestion-free method to chemically unfold and ‘scan’ full-length proteins through a nanopore, producing electrical fingerprints