genetic

Science & Nature How populations adapt to their environment is a fundamental question in biology. Yet, we know surprisingly little about this process, especially...

Science & Nature Scientists from around the world are comparing the genetic blueprints of an array of animals to gain new insights into our...

News Published: 04 April 2023 Cormac Sheridan1  Nature Biotechnology (2023)Cite this article Promising gene therapy, gene editing and antisense oligonucleotide approaches herald a new era of cardiac medicine for patients with certain so-far intractable heart conditions. In addition, a trio of agenda-setting papers from the labs of Eric Olson at the University of Texas Southwestern

Science & Nature UK Biobank data reveal 175 gene loci that show nonadditive effects, indicating a role for genetic dominance rather than gene dosage...Read...

Manhattan plot for the cross-ancestry meta-analysis. The results of the cross-ancestry meta-analysis (77,690 AF cases and 1,167,040 controls) are shown. The log10 BFs on the y axis are shown against the genomic positions (hg19) on the x axis. Association signals that reached a genome-wide significance level (log10 BF > 6) are shown in blue if previously reported

Despite the immense progress the identification of disease-associated genetic variants, our understanding of the functional and pathogenic significance of most mutations is still limited. Current technologies screen variants on a large scale, but they lack quantitative measurements and validation, rendering them impractical as universally applicable tools. In Nature Genetics, Niu et al. report CRISPR-Select, a