{"id":932270,"date":"2026-09-06T11:14:56","date_gmt":"2026-09-06T16:14:56","guid":{"rendered":"https:\/\/newsycanuse.com\/index.php\/2026\/09\/06\/breaking-through-alphafolds-limits-to-predict-how-proteins-change-shape\/"},"modified":"2026-09-06T11:14:56","modified_gmt":"2026-09-06T16:14:56","slug":"breaking-through-alphafolds-limits-to-predict-how-proteins-change-shape","status":"publish","type":"post","link":"https:\/\/newsycanuse.com\/index.php\/2026\/09\/06\/breaking-through-alphafolds-limits-to-predict-how-proteins-change-shape\/","title":{"rendered":"Breaking through AlphaFold&#8217;s limits to predict how proteins change shape"},"content":{"rendered":"<p>Science &#038; Nature Conformational changes in proteins are vital to their function yet remain challenging for state-of-the-art artificial intelligence, such as AlphaFold3, to predict. Researchers at the Institute for Molecular Science (IMS), and the Graduate University for Advanced Studies, SOKENDAI introduced a repulsive force between predicted structures, allowing AlphaFold3 to sample the multiple conformational states that its default settings rarely capture&#8230;<br \/><a href=\"https:\/\/phys.org\/news\/2026-09-alphafold-limits-proteins.html\" class=\"button purchase\" rel=\"nofollow noopener\" target=\"_blank\">Read More<\/a>Elida Grumbles<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Science &#038; Nature Conformational changes in proteins are vital to their function yet remain challenging for state-of-the-art artificial intelligence, such as AlphaFold3, to predict. Researchers at the Institute for Molecular Science (IMS), and the Graduate University for Advanced Studies, SOKENDAI introduced a repulsive force between predicted structures, allowing AlphaFold3 to sample the multiple conformational states [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":932271,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[152238,95,536],"tags":[],"class_list":["post-932270","post","type-post","status-publish","format-standard","has-post-thumbnail","category-alphafolds","category-breaking","category-science-nature"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts\/932270","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/comments?post=932270"}],"version-history":[{"count":0,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts\/932270\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/media\/932271"}],"wp:attachment":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/media?parent=932270"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/categories?post=932270"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/tags?post=932270"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}