{"id":889508,"date":"2026-02-02T02:12:07","date_gmt":"2026-02-02T08:12:07","guid":{"rendered":"https:\/\/newsycanuse.com\/index.php\/2026\/02\/02\/dna-protein-cross-links-promote-cgas-sting-driven-premature-aging-and-embryonic-lethality-science\/"},"modified":"2026-02-02T02:12:07","modified_gmt":"2026-02-02T08:12:07","slug":"dna-protein-cross-links-promote-cgas-sting-driven-premature-aging-and-embryonic-lethality-science","status":"publish","type":"post","link":"https:\/\/newsycanuse.com\/index.php\/2026\/02\/02\/dna-protein-cross-links-promote-cgas-sting-driven-premature-aging-and-embryonic-lethality-science\/","title":{"rendered":"DNA-protein cross-links promote cGAS-STING\u2013driven premature aging and embryonic lethality | Science"},"content":{"rendered":"<p>Science &#038; Nature DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease SPRTN in preventing DPC-driven immunity and its &#8230;<br \/><a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.adx9445\" class=\"button purchase\" rel=\"nofollow noopener\" target=\"_blank\">Read More<\/a>Michele Mongold<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Science &#038; Nature DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease SPRTN in preventing DPC-driven immunity and its &#8230;Read MoreMichele Mongold<\/p>\n","protected":false},"author":1,"featured_media":889509,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[147867,147866,536],"tags":[],"class_list":["post-889508","post","type-post","status-publish","format-standard","has-post-thumbnail","category-cross-links","category-dna-protein","category-science-nature"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts\/889508","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/comments?post=889508"}],"version-history":[{"count":0,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts\/889508\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/media\/889509"}],"wp:attachment":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/media?parent=889508"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/categories?post=889508"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/tags?post=889508"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}