{"id":869203,"date":"2025-08-30T23:13:16","date_gmt":"2025-08-31T04:13:16","guid":{"rendered":"https:\/\/newsycanuse.com\/index.php\/2025\/08\/30\/machine-learning-based-penetrance-of-genetic-variants-science\/"},"modified":"2025-08-30T23:13:16","modified_gmt":"2025-08-31T04:13:16","slug":"machine-learning-based-penetrance-of-genetic-variants-science","status":"publish","type":"post","link":"https:\/\/newsycanuse.com\/index.php\/2025\/08\/30\/machine-learning-based-penetrance-of-genetic-variants-science\/","title":{"rendered":"Machine learning\u2013based penetrance of genetic variants | Science"},"content":{"rendered":"<p>Science &#038; Nature Accurate variant penetrance estimation is crucial for precision medicine. We constructed machine learning (ML) models for 10 diseases using 1,347,298 participants with electronic health records, then applied them to an independent cohort with linked &#8230;<br \/><a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.adm7066\" class=\"button purchase\" rel=\"nofollow noopener\" target=\"_blank\">Read More<\/a>Diego Schildgen<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Science &#038; Nature Accurate variant penetrance estimation is crucial for precision medicine. We constructed machine learning (ML) models for 10 diseases using 1,347,298 participants with electronic health records, then applied them to an independent cohort with linked &#8230;Read MoreDiego Schildgen<\/p>\n","protected":false},"author":1,"featured_media":869204,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42439,4889,536],"tags":[],"class_list":["post-869203","post","type-post","status-publish","format-standard","has-post-thumbnail","category-learning-based","category-machine","category-science-nature"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts\/869203","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/comments?post=869203"}],"version-history":[{"count":0,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts\/869203\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/media\/869204"}],"wp:attachment":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/media?parent=869203"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/categories?post=869203"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/tags?post=869203"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}