{"id":860803,"date":"2025-07-07T21:11:51","date_gmt":"2025-07-08T02:11:51","guid":{"rendered":"https:\/\/newsycanuse.com\/index.php\/2025\/07\/07\/mining-the-crbn-target-space-redefines-rules-for-molecular-glue-induced-neosubstrate-recognition-science\/"},"modified":"2025-07-07T21:11:51","modified_gmt":"2025-07-08T02:11:51","slug":"mining-the-crbn-target-space-redefines-rules-for-molecular-glue-induced-neosubstrate-recognition-science","status":"publish","type":"post","link":"https:\/\/newsycanuse.com\/index.php\/2025\/07\/07\/mining-the-crbn-target-space-redefines-rules-for-molecular-glue-induced-neosubstrate-recognition-science\/","title":{"rendered":"Mining the CRBN target space redefines rules for molecular glue\u2013induced neosubstrate recognition | Science"},"content":{"rendered":"<p>Science &#038; Nature The CRL4CRBN E3 ubiquitin ligase is the target of molecular glue degrader compounds that reprogram ligase specificity to induce the degradation of clinically relevant neosubstrate proteins. Known cereblon (CRBN) neosubstrates share a generalizable \u03b2&#8230;<br \/><a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.adt6736\" class=\"button purchase\" rel=\"nofollow noopener\" target=\"_blank\">Read More<\/a>Anthony Latson<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Science &#038; Nature The CRL4CRBN E3 ubiquitin ligase is the target of molecular glue degrader compounds that reprogram ligase specificity to induce the degradation of clinically relevant neosubstrate proteins. Known cereblon (CRBN) neosubstrates share a generalizable \u03b2&#8230;Read MoreAnthony Latson<\/p>\n","protected":false},"author":1,"featured_media":860804,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[107,24322,536],"tags":[],"class_list":{"0":"post-860803","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-target","8":"category-mining","9":"category-science-nature"},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts\/860803","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/comments?post=860803"}],"version-history":[{"count":0,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts\/860803\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/media\/860804"}],"wp:attachment":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/media?parent=860803"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/categories?post=860803"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/tags?post=860803"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}