{"id":823309,"date":"2025-01-31T10:12:43","date_gmt":"2025-01-31T16:12:43","guid":{"rendered":"https:\/\/newsycanuse.com\/index.php\/2025\/01\/31\/randomizing-the-human-genome-by-engineering-recombination-between-repeat-elements-science\/"},"modified":"2025-01-31T10:12:43","modified_gmt":"2025-01-31T16:12:43","slug":"randomizing-the-human-genome-by-engineering-recombination-between-repeat-elements-science","status":"publish","type":"post","link":"https:\/\/newsycanuse.com\/index.php\/2025\/01\/31\/randomizing-the-human-genome-by-engineering-recombination-between-repeat-elements-science\/","title":{"rendered":"Randomizing the human genome by engineering recombination between repeat elements | Science"},"content":{"rendered":"<p>Science &#038; Nature We lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to insert recombination handles into repetitive sequences, up to 1697 per cell line, which &#8230;<br \/><a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.ado3979\" class=\"button purchase\" rel=\"nofollow noopener\" target=\"_blank\">Read More<\/a>Dion Wrona<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Science &#038; Nature We lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to insert recombination handles into repetitive sequences, up to 1697 per cell line, which &#8230;Read MoreDion Wrona<\/p>\n","protected":false},"author":1,"featured_media":823310,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[568,141296,536],"tags":[],"class_list":["post-823309","post","type-post","status-publish","format-standard","has-post-thumbnail","category-human","category-randomizing","category-science-nature"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts\/823309","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/comments?post=823309"}],"version-history":[{"count":0,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts\/823309\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/media\/823310"}],"wp:attachment":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/media?parent=823309"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/categories?post=823309"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/tags?post=823309"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}