{"id":822379,"date":"2025-01-27T10:11:59","date_gmt":"2025-01-27T16:11:59","guid":{"rendered":"https:\/\/newsycanuse.com\/index.php\/2025\/01\/27\/lysosomal-dysfunction-and-inflammatory-sterol-metabolism-in-pulmonary-arterial-hypertension-science\/"},"modified":"2025-01-27T10:11:59","modified_gmt":"2025-01-27T16:11:59","slug":"lysosomal-dysfunction-and-inflammatory-sterol-metabolism-in-pulmonary-arterial-hypertension-science","status":"publish","type":"post","link":"https:\/\/newsycanuse.com\/index.php\/2025\/01\/27\/lysosomal-dysfunction-and-inflammatory-sterol-metabolism-in-pulmonary-arterial-hypertension-science\/","title":{"rendered":"Lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension | Science"},"content":{"rendered":"<p>Science &#038; Nature Vascular inflammation regulates endothelial pathophenotypes, particularly in pulmonary arterial hypertension (PAH). Dysregulated lysosomal activity and cholesterol metabolism activate pathogenic inflammation, but their relevance to PAH is unclear. &#8230;<br \/><a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.adn7277\" class=\"button purchase\" rel=\"nofollow noopener\" target=\"_blank\">Read More<\/a>Alejandro Mayoral<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Science &#038; Nature Vascular inflammation regulates endothelial pathophenotypes, particularly in pulmonary arterial hypertension (PAH). Dysregulated lysosomal activity and cholesterol metabolism activate pathogenic inflammation, but their relevance to PAH is unclear. &#8230;Read MoreAlejandro Mayoral<\/p>\n","protected":false},"author":1,"featured_media":822380,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[31644,113659,536],"tags":[],"class_list":{"0":"post-822379","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-dysfunction","8":"category-lysosomal","9":"category-science-nature"},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts\/822379","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/comments?post=822379"}],"version-history":[{"count":0,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts\/822379\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/media\/822380"}],"wp:attachment":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/media?parent=822379"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/categories?post=822379"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/tags?post=822379"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}