{"id":812717,"date":"2024-12-17T22:24:44","date_gmt":"2024-12-18T04:24:44","guid":{"rendered":"https:\/\/newsycanuse.com\/index.php\/2024\/12\/17\/new-study-common-hospital-infection-could-trigger-alzheimers\/"},"modified":"2024-12-17T22:24:44","modified_gmt":"2024-12-18T04:24:44","slug":"new-study-common-hospital-infection-could-trigger-alzheimers","status":"publish","type":"post","link":"https:\/\/newsycanuse.com\/index.php\/2024\/12\/17\/new-study-common-hospital-infection-could-trigger-alzheimers\/","title":{"rendered":"New Study: Common Hospital Infection Could Trigger Alzheimer\u2019s"},"content":{"rendered":"
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\"Gut<\/a>
A study from Florida State University links the gut bacteria Klebsiella pneumoniae with Alzheimer\u2019s progression, demonstrating its migration from the gut to the brain and subsequent neuroinflammation.<\/figcaption><\/figure>\n

Florida State researchers discovered that gut bacteria, like Klebsiella pneumoniae<\/em>, may reach the brain and exacerbate Alzheimer\u2019s<\/div>\n

Alzheimer's disease is a progressive neurological disorder that primarily affects older adults, leading to memory loss, cognitive decline, and behavioral changes. It is the most common cause of dementia. The disease is characterized by the buildup of amyloid plaques and tau tangles in the brain, which disrupt cell function and communication. There is currently no cure, and treatments focus on managing symptoms and improving quality of life.<\/div>\n

” data-gt-translate-attributes=”[{“attribute”:”data-cmtooltip”, “format”:”html”}]” tabindex=”0″ role=”link”>Alzheimer\u2019s<\/span> disease symptoms. The study emphasizes the risks of hospital-acquired infections and gut microbiome disruptions for cognitive health.<\/strong><\/p>\n

Researchers at Florida State University<\/div>\n

Florida State University (Florida State or FSU) is a public space-grant and sea-grant research university in Tallahassee, Florida, United States that was established in 1851. The university comprises 16 separate colleges and more than 110 centers, facilities, labs, and institutes that offer more than 360 programs of study, including professional school programs.<\/div>\n

” data-gt-translate-attributes=”[{“attribute”:”data-cmtooltip”, “format”:”html”}]” tabindex=”0″ role=”link”>Florida State University<\/span>\u2019s Gut Biome Lab<\/a> have conducted a groundbreaking study uncovering a possible connection between gut bacterial infections and the progression of Alzheimer\u2019s disease.<\/p>\n

The research found that the bacteria Klebsiella pneumoniae<\/em> \u2014 a common bacteria notorious for causing hospital-acquired infections \u2014 can migrate from the gut into the bloodstream and eventually into the brain. This bacterial invasion may lead to increased inflammation in the brain and impair cognitive functions, mimicking symptoms seen in Alzheimer\u2019s patients. The work was published in The Journal of Infectious Diseases.<\/em><\/p>\n

\u201cHospitalizations and ICU stays, combined with antibiotic exposure, may lead to a further decline in microbiome diversity that leaves older adults at high risk not only for digestive issues but also for extra-intestinal pathologies such as neurodegenerative disorders through a dysregulation of the gut-brain axis,\u201d said Ravinder Nagpal, an assistant professor in the FSU College of Education, Health, and Human Sciences and the director of the Gut Biome Lab.<\/p>\n

Study Findings on K. pneumoniae and Alzheimer\u2019s Pathology<\/h4>\n

The study is the first to show a direct correlation between K. pneumoniae <\/em>infection and Alzheimer\u2019s pathology, fueling the emerging field that investigates how infectious agents may trigger or aggravate Alzheimer\u2019s disease. It also paves the way for future research into how to treat harmful infectious agents in vulnerable populations such as the elderly or those recovering from sepsis.<\/p>\n

\"Ravinder<\/a>
Ravinder Nagpal, an assistant professor in the FSU College of Education, Health, and Human Sciences and the director of the Gut Biome Lab, led a study that revealed a potential link between an infection caused by gut bacteria and the progression of Alzheimer\u2019s disease. Credit: Florida State University<\/figcaption><\/figure>\n

The research suggests that when antibiotics disrupt the gut, it can lead to issues not just in the gut but also in the brain. Using a preclinical mouse model, researchers showed that antibiotic exposure depletes gut bacterial diversity and causes microbiome imbalance, which promotes the proliferation of K. pneumoniae<\/em> by creating a favorable niche.<\/p>\n

Implications for Hospital-Acquired Infections and Alzheimer\u2019s Risk<\/h4>\n

When this happens, K. pneumoniae<\/em> can move from the gut into the bloodstream by passing through the gut lining and eventually reach the brain, triggering neuroinflammation and neurocognitive impairment.<\/p>\n

The findings emphasize the potential risk hospital-acquired infections like K. pneumoniae <\/em>may pose in the development of neurodegenerative diseases.<\/p>\n

\u201cHospital-acquired and septic infections are one of the risk factors that may increase the predispositions to future neuroinflammatory and neurocognitive impairments, especially in older adults,\u201d Nagpal said.<\/p>\n

The study highlights the need for innovative therapeutic approaches to combat the rising prevalence of Alzheimer\u2019s disease, in addition to existing amyloid and tau protein therapies. Further research could provide insight into preventive strategies aimed at managing hospital-acquired pathogens and preserving cognitive health in aging populations.<\/p>\n

Reference: \u201cAn Enteric Bacterial Infection Triggers Neuroinflammation and Neurobehavioral Impairment in 3xTg-AD Transgenic Mice\u201d by Gwoncheol Park, Saurabh Kadyan, Nathaniel Hochuli, Gloria Salazar, Orlando Laitano, Paramita Chakrabarty, Philip A Efron, M Ammar Zafar, Aaron Wilber and Ravinder Nagpal, 10 September 2024, The Journal of Infectious Diseases<\/i>.
\nDOI: 10.1093\/infdis\/jiae165<\/a><\/p>\n

The research was funded by the Infectious Diseases Society of America and the Florida Department of Health.<\/p>\n<\/p><\/div>\n

\t\t\t Florida State University
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A study from Florida State University links the gut bacteria Klebsiella pneumoniae with Alzheimer\u2019s progression, demonstrating its migration from the gut to the brain and subsequent neuroinflammation. Florida State researchers discovered that gut bacteria, like Klebsiella pneumoniae, may reach the brain and exacerbate Alzheimer\u2019s disease symptoms. The study emphasizes the risks of hospital-acquired infections and<\/p>\n","protected":false},"author":1,"featured_media":812718,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22742,3437],"tags":[9740,8870],"class_list":{"0":"post-812717","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-common","8":"category-study","9":"tag-common","10":"tag-study"},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts\/812717","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/comments?post=812717"}],"version-history":[{"count":0,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts\/812717\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/media\/812718"}],"wp:attachment":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/media?parent=812717"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/categories?post=812717"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/tags?post=812717"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}