{"id":625846,"date":"2023-04-05T10:49:55","date_gmt":"2023-04-05T15:49:55","guid":{"rendered":"https:\/\/news.sellorbuyhomefast.com\/index.php\/2023\/04\/05\/genetic-medicines-aim-straight-for-the-heart\/"},"modified":"2023-04-05T10:49:55","modified_gmt":"2023-04-05T15:49:55","slug":"genetic-medicines-aim-straight-for-the-heart","status":"publish","type":"post","link":"https:\/\/newsycanuse.com\/index.php\/2023\/04\/05\/genetic-medicines-aim-straight-for-the-heart\/","title":{"rendered":"Genetic medicines aim straight for the heart"},"content":{"rendered":"<p>Science &#038; Nature <\/p>\n<div>\n<header>\n<ul data-test=\"article-identifier\">\n<li data-test=\"article-category\">News<\/li>\n<li><a href=\"http:\/\/www.nature.com\/#article-info\" data-track=\"click\" data-track-action=\"publication date\" data-track-label=\"link\">Published: <time datetime=\"2023-04-04\">04 April 2023<\/time><\/a><\/li>\n<\/ul>\n<ul data-test=\"authors-list\" data-component-authors-activator=\"authors-list\">\n<li><a data-test=\"author-name\" data-track=\"click\" data-track-action=\"open author\" data-track-label=\"link\" href=\"http:\/\/www.nature.com\/#auth-Cormac-Sheridan\" data-author-popup=\"auth-Cormac-Sheridan\">Cormac Sheridan<\/a><sup><a href=\"http:\/\/www.nature.com\/#Aff1\">1<\/a><\/sup>\u00a0<\/li>\n<\/ul>\n<p data-container-section=\"info\">\n<p>    <a data-test=\"journal-link\" href=\"http:\/\/www.nature.com\/nbt\" data-track=\"click\" data-track-action=\"journal homepage\" data-track-category=\"article body\" data-track-label=\"link\"><i data-test=\"journal-title\">Nature Biotechnology<\/i><\/a><\/p>\n<p>                         (<span data-test=\"article-publication-year\">2023<\/span>)<a href=\"http:\/\/www.nature.com\/#citeas\" data-track=\"click\" data-track-action=\"cite this article\" data-track-label=\"link\">Cite this article<\/a>\n                    <\/p>\n<\/header><\/div>\n<div>\n<p>Promising gene therapy, gene editing and antisense oligonucleotide approaches herald a new era of cardiac medicine for patients with certain so-far intractable heart conditions.<\/p>\n<p>In addition, a trio of agenda-setting papers from the labs of Eric Olson at the University of Texas Southwestern Medical Center and a complementary study from Christine Seidman\u2019s lab at Harvard Medical School have shown that CRISPR\u2013Cas9 editing, base editing and prime editing can all be harnessed to correct genetic models of cardiac disease in mice. Technical proof of concept has now been established for tackling cardiomyopathies caused by mutations in the <i>MYH7<\/i> and the <i>RBM20<\/i> genes, as well as for disrupting a pathological signaling mechanism caused by chronic overactivation of calcium\/calmodulin-dependent protein kinase II\u03b4 that is present in many patients with heart failure.<\/p>\n<div>\n<p>This is a preview of subscription content, <a href=\"https:\/\/wayf.springernature.com?redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41587-023-01745-4\" data-track=\"click\" data-track-action=\"institution access preview subscription\" data-track-label=\"link\">access via your institution<\/a><\/p>\n<\/p><\/div>\n<h2 id=\"access-options\">Access options<\/h2>\n<section>\n<div>\n<p>Access Nature and 54 other Nature Portfolio journals<\/p>\n<p>Get Nature+, our best-value online-access subscription<\/p>\n<div>\n<p id=\"nature-plus-subscription-price\">$29.99 per month<\/p>\n<p>cancel any 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Ireland<\/p>\n<p>Cormac Sheridan<\/p>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<div id=\"rightslink-section\" data-title=\"Rights and permissions\">\n<h2 id=\"rightslink\">Rights and permissions<\/h2>\n<\/div>\n<div id=\"article-info-section\" aria-labelledby=\"article-info\" data-title=\"About this article\">\n<h2 id=\"article-info\">About this article<\/h2>\n<div id=\"article-info-content\">\n<p><a data-crossmark=\"10.1038\/s41587-023-01745-4\" target=\"_blank\" rel=\"noopener\" href=\"https:\/\/crossmark.crossref.org\/dialog\/?doi=10.1038\/s41587-023-01745-4\" data-track=\"click\" data-track-action=\"Click Crossmark\" data-track-label=\"link\" data-test=\"crossmark\"><img loading=\"lazy\" decoding=\"async\" width=\"57\" height=\"81\" alt=\"Science &amp; Nature Verify currency and authenticity via CrossMark\" src=\"data:image\/svg+xml;base64,<svg height="81" width="57" xmlns="http://www.w3.org/2000/svg"><g fill="none" fill-rule="evenodd"><path d="m17.35 35.45 21.3-14.2v-17.03h-21.3" 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Genetic medicines aim straight for the heart.<br \/>\n                    <i>Nat Biotechnol<\/i>  (2023). https:\/\/doi.org\/10.1038\/s41587-023-01745-4<\/p>\n<p><a data-test=\"citation-link\" data-track=\"click\" data-track-action=\"download article citation\" data-track-label=\"link\" data-track-external rel=\"nofollow\" href=\"https:\/\/citation-needed.springer.com\/v2\/references\/10.1038\/s41587-023-01745-4?format=refman&#038;flavour=citation\">Download citation<\/a><\/p>\n<ul data-test=\"publication-history\">\n<li>\n<p>Published<span>: <\/span><span><time datetime=\"2023-04-04\">04 April 2023<\/time><\/span><\/p>\n<\/li>\n<li>\n<p><abbr title=\"Digital Object Identifier\">DOI<\/abbr><span>: <\/span><span>https:\/\/doi.org\/10.1038\/s41587-023-01745-4<\/span><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div><\/div>\n<\/div>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41587-023-01745-4\" class=\"button purchase\" rel=\"nofollow noopener\" target=\"_blank\">Read More<\/a><br \/>\n Cormac Sheridan<\/p>\n","protected":false},"excerpt":{"rendered":"<p>News Published: 04 April 2023 Cormac Sheridan1\u00a0 Nature Biotechnology (2023)Cite this article Promising gene therapy, gene editing and antisense oligonucleotide approaches herald a new era of cardiac medicine for patients with certain so-far intractable heart conditions. In addition, a trio of agenda-setting papers from the labs of Eric Olson at the University of Texas Southwestern<\/p>\n","protected":false},"author":1,"featured_media":625847,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[23551,24078,536],"tags":[],"class_list":{"0":"post-625846","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-genetic","8":"category-medicines","9":"category-science-nature"},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts\/625846","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/comments?post=625846"}],"version-history":[{"count":0,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts\/625846\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/media\/625847"}],"wp:attachment":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/media?parent=625846"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/categories?post=625846"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/tags?post=625846"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}