{"id":616239,"date":"2023-03-10T01:53:55","date_gmt":"2023-03-10T07:53:55","guid":{"rendered":"https:\/\/news.sellorbuyhomefast.com\/index.php\/2023\/03\/10\/engineered-upstream-open-reading-frames-predictably-downregulate-mrna-translation-in-plants\/"},"modified":"2023-03-10T01:53:55","modified_gmt":"2023-03-10T07:53:55","slug":"engineered-upstream-open-reading-frames-predictably-downregulate-mrna-translation-in-plants","status":"publish","type":"post","link":"https:\/\/newsycanuse.com\/index.php\/2023\/03\/10\/engineered-upstream-open-reading-frames-predictably-downregulate-mrna-translation-in-plants\/","title":{"rendered":"Engineered upstream open reading frames predictably downregulate mRNA translation in plants"},"content":{"rendered":"<p>Science &#038; Nature <\/p>\n<div>\n<header>\n<ul data-test=\"article-identifier\">\n<li data-test=\"article-category\">Research Briefing<\/li>\n<li><a href=\"http:\/\/www.nature.com\/#article-info\" data-track=\"click\" data-track-action=\"publication date\" data-track-label=\"link\">Published: <time datetime=\"2023-03-09\">09 March 2023<\/time><\/a><\/li>\n<\/ul>\n<ul data-test=\"authors-list\" data-component-authors-activator=\"authors-list\"><\/ul>\n<p data-container-section=\"info\">\n<p>    <a data-test=\"journal-link\" href=\"http:\/\/www.nature.com\/nbt\" data-track=\"click\" data-track-action=\"journal homepage\" data-track-category=\"article body\" data-track-label=\"link\"><i data-test=\"journal-title\">Nature Biotechnology<\/i><\/a><\/p>\n<p>                         (<span data-test=\"article-publication-year\">2023<\/span>)<a href=\"http:\/\/www.nature.com\/#citeas\" data-track=\"click\" data-track-action=\"cite this article\" data-track-label=\"link\">Cite this article<\/a>\n                    <\/p>\n<\/header>\n<div data-component=\"article-subject-links\">\n<h3>Subjects<\/h3>\n<\/p><\/div>\n<\/p><\/div>\n<div>\n<p>Fine-tuning gene expression is crucial for generating quantitative phenotypic changes and crop improvement. Using CRISPR\u2013Cas base editing and prime editing, we engineered upstream open reading frames \u2014 eukaryotic translational control elements \u2014 in rice to incrementally downregulate translation to predictable and desired levels.<\/p>\n<div>\n<p>This is a preview of subscription content, <a href=\"https:\/\/wayf.springernature.com?redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41587-023-01729-4\" data-track=\"click\" data-track-action=\"institution access preview subscription\" data-track-label=\"link\">access via your institution<\/a><\/p>\n<\/p><\/div>\n<h2 id=\"access-options\">Access options<\/h2>\n<section>\n<div>\n<p>Access Nature and 54 other Nature Portfolio journals<\/p>\n<p>Get Nature+, our best-value online-access subscription<\/p>\n<div>\n<p id=\"nature-plus-subscription-price\">$29.99 per month<\/p>\n<p>cancel any time<\/p>\n<\/div>\n<\/div>\n<div>\n<p>Subscribe to this journal<\/p>\n<p>Receive 12 print issues and online access<\/p>\n<div>\n<p id=\"subscription-price\">$209.00 per year<\/p>\n<p>only $17.42 per issue<\/p>\n<\/div>\n<\/div>\n<div>\n<p>Rent or buy this article<\/p>\n<p>Get just this article for as long as you need it<\/p>\n<p id=\"readcube-price\">$39.95<\/p>\n<\/div>\n<p>Prices may be subject to local taxes which are calculated during checkout<\/p>\n<\/section>\n<nav>\n<h3>Additional access options:<\/h3>\n<ul>\n<li>\n            <a href=\"https:\/\/idp.nature.com\/authorize\/natureuser?client_id=grover&#038;redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41587-023-01729-4\" data-track=\"click\" data-track-action=\"login\" data-track-category=\"article body\" data-track-label=\"link\">Log in<\/a>\n        <\/li>\n<li>\n            <a href=\"https:\/\/www.springernature.com\/gp\/librarians\/licensing\/license-options\" data-track=\"click\" data-track-action=\"learn-subscription\" data-track-category=\"article body\" data-track-label=\"link\">Learn about institutional subscriptions<\/a>\n        <\/li>\n<li>\n            <a href=\"https:\/\/support.nature.com\/en\/support\/home\" data-track=\"click\" data-track-action=\"read our faqs\" data-track-category=\"article body\" data-track-label=\"link\">Read our FAQs<\/a>\n        <\/li>\n<li>\n            <a href=\"https:\/\/www.springernature.com\/gp\/contact\" data-track=\"click\" data-track-action=\"contact customer support\" data-track-category=\"article body\" data-track-label=\"link\">Contact customer support<\/a>\n        <\/li>\n<\/ul>\n<\/nav>\n<div data-test=\"figure\" data-container-section=\"figure\" id=\"figure-1\">\n<figure><figcaption><b id=\"Fig1\" data-test=\"figure-caption-text\">Fig. 1: Breeding plants with a predicted phenotype by engineering uORFs.<\/b><\/figcaption><div><picture><source type=\"image\/webp\" ><img decoding=\"async\" src=\"http:\/\/media.springernature.com\/m312\/springer-static\/image\/art%3A10.1038%2Fs41587-023-01729-4\/MediaObjects\/41587_2023_1729_Fig1_HTML.png\" alt loading=\"lazy\" width=\"312\" height=\"255\"><\/picture><\/div>\n<\/figure>\n<\/div>\n<div data-enable-entitlement-checks>\n<div id=\"MagazineFulltextArticleBodySuffix\" aria-labelledby=\"Bib1\" data-title=\"References\">\n<h2 id=\"Bib1\">References<\/h2>\n<div data-container-section=\"references\" id=\"Bib1-content\">\n<ol data-track-component=\"outbound reference\">\n<li data-counter=\"1.\">\n<p id=\"ref-CR1\">Gao, C. 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Tuning plant phenotypes by precise, graded downregulation of gene expression. <i>Nat. Biotechnol<\/i>. <a href=\"https:\/\/doi.org\/10.1038\/s41587-023-01707-w\">https:\/\/doi.org\/10.1038\/s41587-023-01707-w<\/a> (2023).<\/p>\n<\/div>\n<\/div>\n<div id=\"rightslink-section\" data-title=\"Rights and permissions\">\n<h2 id=\"rightslink\">Rights and permissions<\/h2>\n<\/div>\n<div id=\"article-info-section\" aria-labelledby=\"article-info\" data-title=\"About this article\">\n<h2 id=\"article-info\">About this article<\/h2>\n<div id=\"article-info-content\">\n<p><a data-crossmark=\"10.1038\/s41587-023-01729-4\" target=\"_blank\" rel=\"noopener\" href=\"https:\/\/crossmark.crossref.org\/dialog\/?doi=10.1038\/s41587-023-01729-4\" data-track=\"click\" data-track-action=\"Click Crossmark\" data-track-label=\"link\" data-test=\"crossmark\"><img loading=\"lazy\" decoding=\"async\" width=\"57\" height=\"81\" alt=\"Science &amp; Nature Verify currency and authenticity via CrossMark\" src=\"data:image\/svg+xml;base64,<svg height="81" width="57" 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1.3zm3.01 2.23c.31.24.61.43.92.57.3.13.63.2.98.2.38 0 .65-.08.83-.23s.27-.35.27-.6c0-.14-.05-.26-.13-.37-.08-.1-.2-.2-.34-.28-.14-.09-.29-.16-.47-.23l-.53-.22c-.23-.09-.46-.18-.69-.3-.23-.11-.44-.24-.62-.4s-.33-.35-.45-.55c-.12-.21-.18-.46-.18-.75 0-.61.23-1.1.68-1.49.44-.38 1.06-.57 1.83-.57.48 0 .91.08 1.29.25s.71.36.99.57l-.74.98c-.24-.17-.49-.32-.73-.42-.25-.11-.51-.16-.78-.16-.35 0-.6.07-.76.21-.17.15-.25.33-.25.54 0 .14.04.26.12.36s.18.18.31.26c.14.07.29.14.46.21l.54.19c.23.09.47.18.7.29s.44.24.64.4c.19.16.34.35.46.58.11.23.17.5.17.82 0 .3-.06.58-.17.83-.12.26-.29.48-.51.68-.23.19-.51.34-.84.45-.34.11-.72.17-1.15.17-.48 0-.95-.09-1.41-.27-.46-.19-.86-.41-1.2-.68z" fill="#535353"/></g></svg>\"><\/a><\/p>\n<div>\n<h3 id=\"citeas\">Cite this article<\/h3>\n<p> Engineered upstream open reading frames predictably downregulate mRNA translation in plants.<br \/>\n                    <i>Nat Biotechnol<\/i>  (2023). https:\/\/doi.org\/10.1038\/s41587-023-01729-4<\/p>\n<p><a data-test=\"citation-link\" data-track=\"click\" data-track-action=\"download article citation\" data-track-label=\"link\" data-track-external rel=\"nofollow\" href=\"https:\/\/citation-needed.springer.com\/v2\/references\/10.1038\/s41587-023-01729-4?format=refman&#038;flavour=citation\">Download citation<\/a><\/p>\n<ul data-test=\"publication-history\">\n<li>\n<p>Published<span>: <\/span><span><time datetime=\"2023-03-09\">09 March 2023<\/time><\/span><\/p>\n<\/li>\n<li>\n<p><abbr title=\"Digital Object Identifier\">DOI<\/abbr><span>: <\/span><span>https:\/\/doi.org\/10.1038\/s41587-023-01729-4<\/span><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div><\/div>\n<\/div>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41587-023-01729-4\" class=\"button purchase\" rel=\"nofollow noopener\" target=\"_blank\">Read More<\/a><br \/>\n Margherita Wrona<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research Briefing Published: 09 March 2023 Nature Biotechnology (2023)Cite this article Subjects Fine-tuning gene expression is crucial for generating quantitative phenotypic changes and crop improvement. Using CRISPR\u2013Cas base editing and prime editing, we engineered upstream open reading frames \u2014 eukaryotic translational control elements \u2014 in rice to incrementally downregulate translation to predictable and desired levels.<\/p>\n","protected":false},"author":1,"featured_media":616240,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[30978,536,97118],"tags":[],"class_list":["post-616239","post","type-post","status-publish","format-standard","has-post-thumbnail","category-engineered","category-science-nature","category-upstream"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts\/616239","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/comments?post=616239"}],"version-history":[{"count":0,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts\/616239\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/media\/616240"}],"wp:attachment":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/media?parent=616239"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/categories?post=616239"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/tags?post=616239"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}