{"id":616171,"date":"2023-03-09T17:49:52","date_gmt":"2023-03-09T23:49:52","guid":{"rendered":"https:\/\/news.sellorbuyhomefast.com\/index.php\/2023\/03\/09\/autopsies-show-relationship-between-alzheimers-pathology-and-diet-in-older-adults\/"},"modified":"2023-03-09T17:49:52","modified_gmt":"2023-03-09T23:49:52","slug":"autopsies-show-relationship-between-alzheimers-pathology-and-diet-in-older-adults","status":"publish","type":"post","link":"https:\/\/newsycanuse.com\/index.php\/2023\/03\/09\/autopsies-show-relationship-between-alzheimers-pathology-and-diet-in-older-adults\/","title":{"rendered":"Autopsies Show Relationship Between Alzheimer&#8217;s Pathology and Diet in Older Adults"},"content":{"rendered":"<div>\n<nav>\n      <a href=\"http:\/\/www.medpagetoday.com\/neurology\" tabindex=\"15.1\" itemprop=\"articleSection\">Neurology<\/a><br \/>\n      <span>><\/span><br \/>\n      <a href=\"http:\/\/www.medpagetoday.com\/neurology\/alzheimersdisease\" tabindex=\"15.2\">Alzheimer&#8217;s Disease<\/a><br \/>\n  <\/nav>\n<h2>\u2014 Green leafy vegetable intake inversely correlated with pathology in postmortem brain tissue<\/h2>\n<p>\n      by<br \/>\n             <a href=\"https:\/\/www.medpagetoday.com\/people\/jg8109\/judy-george\">Judy George<\/a>, Deputy Managing Editor, MedPage Today                        <span itemprop=\"datePublished\" content=\"March 8, 2023\"><br \/>\n        March 8, 2023<br \/>\n      <\/span>\n          <\/p>\n<\/div>\n<div id=\"js-main-content-region\" itemtype=\"http:\/\/schema.org\/articleBody\" itemid=\"#main-content-region\">\n<p>Healthy, plant-based dietary patterns were linked with less postmortem Alzheimer&#8217;s disease pathology, primarily beta-amyloid load, in older adults.<\/p>\n<p>Both MIND diet scores (\u03b2 -0.022, <em>P<\/em>=0.035; standardized beta -2.0) and Mediterranean diet scores (\u03b2 -0.007, <em>P<\/em>=0.039; standardized beta -2.3) were significantly associated with lower global Alzheimer&#8217;s pathology, reported Puja Agarwal, PhD, of Rush University in Chicago, and co-authors.<\/p>\n<p>MIND and Mediterranean diets were also associated with less beta-amyloid at autopsy (MIND standardized beta -2.0, Mediterranean standardized beta -2.9), the researchers wrote in <a href=\"https:\/\/n.neurology.org\/lookup\/doi\/10.1212\/WNL.0000000000207176\" target=\"_blank\" rel=\"noopener\"><em>Neurology<\/em><\/a>.<\/p>\n<p>People who had the highest intake of green leafy vegetables  &#8212;  7 or more servings per week  &#8212;  had less global Alzheimer&#8217;s pathology than those who ate only 1 or 2 servings weekly (tertile 3 vs tertile 1: \u03b2 -0.115, <em>P<\/em>=0.0038). None of the diet scores had an association with phosphorylated tau tangles.<\/p>\n<p>The study assessed <a href=\"https:\/\/www.hsph.harvard.edu\/nutritionsource\/healthy-weight\/diet-reviews\/mind-diet\/\" target=\"_blank\" rel=\"noopener\">MIND<\/a> and <a href=\"https:\/\/www.hsph.harvard.edu\/nutritionsource\/healthy-weight\/diet-reviews\/mediterranean-diet\/\" target=\"_blank\" rel=\"noopener\">Mediterranean<\/a> dietary patterns in 581 autopsied participants. Both diets are rich in nutrients and bioactive compounds and have antioxidant properties.<\/p>\n<p>The Mediterranean diet recommends vegetables, fruit, and three or more servings of fish a week. The MIND diet prioritizes green leafy vegetables like spinach, kale, collard greens, and other vegetables, prioritizes berries over other fruit, and recommends one or more servings of fish a week. Both recommend small amounts of wine.<\/p>\n<p>Associations between dietary patterns and Alzheimer&#8217;s pathology <a href=\"https:\/\/www.medpagetoday.com\/neurology\/alzheimersdisease\/92460\" target=\"_blank\" rel=\"noopener\">have been suggested<\/a> in earlier work using imaging and cerebrospinal fluid biomarkers. &#8220;A large body of evidence links a healthy diet and nutritional intake with a lower risk of developing Alzheimer&#8217;s disease,&#8221; noted Lisa Mosconi, PhD, of Weill Cornell Medicine in New York City, who wasn&#8217;t involved with the study.<\/p>\n<p>&#8220;This important study corroborates previous research by showing that elderly individuals following either a Mediterranean diet or MIND diet exhibit a lower burden of Alzheimer&#8217;s pathology in their brains,&#8221; Mosconi told<em> MedPage Today<\/em>. &#8220;Although more clinical trials are needed, recommending targeted dietary interventions is evidence-based and safe for reducing the risk of Alzheimer&#8217;s dementia.&#8221;<\/p>\n<p>Agarwal and colleagues analyzed data from the longitudinal Rush Memory and Aging Project cohort, a prospective study of older adults who agreed to annual clinical evaluations and brain donation at death. They followed 581 people with a mean age of 84 at their first dietary assessment and a mean age of 91 at death. Participants completed annual food frequency questionnaires.<\/p>\n<p>Mean follow-up was 6.8 years, and 73% of participants were women. Proximate to death, 38.5% of participants had a diagnosis of clinical dementia. At autopsy, 66% had a pathologic diagnosis of Alzheimer&#8217;s disease.<\/p>\n<p>Mediterranean diet scores had 11 dietary components and ranged from 0 to 55. MIND diet scores had 15 components and ranged from 0 to 15. Mediterranean diet scores in the top tertile were an average of 35; in the bottom tertile they were 26. MIND diet scores in the top tertile were an average of 9.1; in the bottom tertile they were 5.9.<\/p>\n<p>Autopsy data included beta-amyloid load, phosphorylated tau tangles, and global AD pathology (summarized neurofibrillary tangles, neuritic and diffuse plaques). Regression models controlled for age at death, sex, education, <em>APOE4<\/em> status, and total calories. Findings persisted when adjusted further for physical activity, smoking, and vascular disease burden, and when participants with mild cognitive impairment or dementia were excluded.<\/p>\n<p>&#8220;For clinical context, we calculated the ratio of the coefficients and found that a MIND diet score one point higher corresponded to typical plaque deposition of participants who are 4.25 years younger in age, with other characteristics being the same,&#8221; Agarwal and colleagues noted.<\/p>\n<p>The study had several limitations, the researchers acknowledged. Its observational design limited the ability to establish causal relationships. In addition, participants were mostly white older adults; findings may not apply to younger people or to more diverse populations.<\/p>\n<div>\n<ul>\n<li>\n<p><a href=\"https:\/\/www.medpagetoday.com\/people\/jg8109\/judy-george\">Judy George<\/a> covers neurology and neuroscience news for MedPage Today, writing about brain aging, Alzheimer\u2019s, dementia, MS, rare diseases, epilepsy, autism, headache, stroke, Parkinson\u2019s, ALS, concussion, CTE, sleep, pain, and more.  <a href=\"https:\/\/twitter.com\/MedPageNeuro\">Follow <span><\/span><\/a>  <\/p>\n<\/li>\n<\/ul><\/div>\n<div>\n<div>\n<p>Disclosures<\/p>\n<div>\n<p>This study was supported by grants from the National Institutes of Health.<\/p>\n<p>The authors reported no relevant disclosures.<\/p>\n<\/div><\/div>\n<div>\n<p>Primary Source<\/p>\n<p>Neurology<\/p>\n<p><a href=\"https:\/\/n.neurology.org\/lookup\/doi\/10.1212\/WNL.0000000000207176\" title=\"Opens in a new tab or window\" target=\"_blank\" rel=\"noopener\">Source Reference: <\/a>Agarwal P, et al &#8220;Association of Mediterranean-DASH intervention for neurodegenerative delay and Mediterranean diets with Alzheimer disease pathology&#8221; Neurology 2023; DOI: 10.1212\/WNL.0000000000207176.<\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<p><a href=\"https:\/\/www.medpagetoday.com\/neurology\/alzheimersdisease\/103459\" class=\"button purchase\" rel=\"nofollow noopener\" target=\"_blank\">Read More<\/a><br \/>\n Qiana Pingree<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Neurology &gt; Alzheimer&#8217;s Disease \u2014 Green leafy vegetable intake inversely correlated with pathology in postmortem brain tissue by Judy George, Deputy Managing Editor, MedPage Today March 8, 2023 Healthy, plant-based dietary patterns were linked with less postmortem Alzheimer&#8217;s disease pathology, primarily beta-amyloid load, in older adults. Both MIND diet scores (\u03b2 -0.022, P=0.035; standardized beta<\/p>\n","protected":false},"author":1,"featured_media":616172,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[39713,3860],"tags":[],"class_list":["post-616171","post","type-post","status-publish","format-standard","has-post-thumbnail","category-autopsies","category-relationship"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts\/616171","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/comments?post=616171"}],"version-history":[{"count":0,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts\/616171\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/media\/616172"}],"wp:attachment":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/media?parent=616171"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/categories?post=616171"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/tags?post=616171"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}