{"id":602605,"date":"2023-01-29T14:50:24","date_gmt":"2023-01-29T20:50:24","guid":{"rendered":"https:\/\/news.sellorbuyhomefast.com\/index.php\/2023\/01\/29\/hallucinating-functional-protein-sequences\/"},"modified":"2023-01-29T14:50:24","modified_gmt":"2023-01-29T20:50:24","slug":"hallucinating-functional-protein-sequences","status":"publish","type":"post","link":"https:\/\/newsycanuse.com\/index.php\/2023\/01\/29\/hallucinating-functional-protein-sequences\/","title":{"rendered":"Hallucinating functional protein sequences"},"content":{"rendered":"<div data-track-component=\"article body\">\n<article lang=\"en\">\n<div>\n<header>\n<ul data-test=\"article-identifier\">\n<li data-test=\"article-category\">News &#038; Views<\/li>\n<li><a href=\"http:\/\/www.nature.com\/#article-info\" data-track=\"click\" data-track-action=\"publication date\" data-track-label=\"link\">Published: <time datetime=\"2023-01-26\">26 January 2023<\/time><\/a><\/li>\n<\/ul>\n<p>Protein engineering<\/p>\n<p data-container-section=\"info\">\n<p>    <a data-test=\"journal-link\" href=\"http:\/\/www.nature.com\/nbt\"><i data-test=\"journal-title\">Nature Biotechnology<\/i><\/a><\/p>\n<p>                         (<span data-test=\"article-publication-year\">2023<\/span>)<a href=\"http:\/\/www.nature.com\/#citeas\" data-track=\"click\" data-track-action=\"cite this article\" data-track-label=\"link\">Cite this article<\/a>\n                    <\/p>\n<div>\n<ul>\n<li>\n<p>640 <span>Accesses<\/span><\/p>\n<\/li>\n<li>\n<p>7 <span>Altmetric<\/span><\/p>\n<\/li>\n<li>\n<p><a href=\"http:\/\/www.nature.com\/articles\/s41587-022-01634-2\/metrics\" data-track=\"click\" data-track-action=\"view metrics\" data-track-label=\"link\" rel=\"nofollow\">Metrics <span>details<\/span><\/a><\/p>\n<\/li>\n<\/ul><\/div>\n<\/header>\n<div data-component=\"article-subject-links\">\n<h3>Subjects<\/h3>\n<\/p><\/div>\n<\/p><\/div>\n<div>\n<p>Functional proteins with limited homology to natural proteins are designed using a large language model.<\/p>\n<p>Directed evolution has proven remarkably successful at finding variants of known proteins with enhanced properties<sup><a data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Reference 1\" title=\"Arnold, F. H. Angew. Chem. Int. Ed. Engl. 58, 14420\u201314426 (2019).\" href=\"http:\/\/www.nature.com\/articles\/s41587-022-01634-2#ref-CR1\" id=\"ref-link-section-d272050763e301\">1<\/a><\/sup>. Yet designing proteins that are not homologous to those found in nature is extremely challenging. The strategy of walking uphill on a rugged protein fitness landscape can stall at local optima, making it hard to discover diverse functional variants. Techniques such as DNA shuffling recombine parental variants and allow larger moves in sequence space, but diverse variants are rarely generated because the synthesis process favors sequence-similar parents.<\/p>\n<div>\n<p>This is a preview of subscription content, <a href=\"https:\/\/wayf.springernature.com?redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41587-022-01634-2\" data-track=\"click\" data-track-action=\"institution access preview subscription\" data-track-label=\"link\">access via your institution<\/a><\/p>\n<\/p><\/div>\n<h2 id=\"access-options\">Access options<\/h2>\n<section>\n<div>\n<p>Subscribe to Nature+<\/p>\n<p>Get immediate online access to Nature and 55 other Nature journal<\/p>\n<\/div>\n<div>\n<p>Subscribe to Journal<\/p>\n<p>Get full journal access for 1 year<\/p>\n<div>\n<p id=\"subscription-price\">$99.00<\/p>\n<p>only $8.25 per issue<\/p>\n<\/div>\n<p>All prices are NET prices.<br \/> VAT will be added later in the checkout.<br \/>Tax calculation will be finalised during checkout.<\/p>\n<\/div>\n<div>\n<p>Buy article<\/p>\n<p>Get time limited or full article access on ReadCube.<\/p>\n<p id=\"readcube-price\">$32.00<\/p>\n<p>All prices are NET prices.<\/p>\n<\/div>\n<\/section>\n<nav>\n<h3>Additional access options:<\/h3>\n<ul>\n<li>\n            <a href=\"https:\/\/idp.nature.com\/authorize\/natureuser?client_id=grover&#038;redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41587-022-01634-2\" data-track=\"click\" data-track-action=\"login\" data-track-category=\"article body\" data-track-label=\"link\">Log in<\/a>\n        <\/li>\n<li>\n            <a href=\"https:\/\/www.springernature.com\/gp\/librarians\/licensing\/license-options\" data-track=\"click\" data-track-action=\"learn-subscription\" data-track-category=\"article body\" data-track-label=\"link\">Learn about institutional subscriptions<\/a>\n        <\/li>\n<\/ul>\n<\/nav>\n<div data-test=\"figure\" data-container-section=\"figure\" id=\"figure-1\">\n<figure><figcaption><b id=\"Fig1\" data-test=\"figure-caption-text\">Fig. 1: ProGen.<\/b><\/figcaption><div><picture><source type=\"image\/webp\" ><img decoding=\"async\" src=\"http:\/\/media.springernature.com\/m312\/springer-static\/image\/art%3A10.1038%2Fs41587-022-01634-2\/MediaObjects\/41587_2022_1634_Fig1_HTML.png\" alt loading=\"lazy\" width=\"312\" height=\"223\"><\/picture><\/div>\n<\/figure>\n<\/div>\n<div>\n<div id=\"MagazineFulltextArticleBodySuffix\" aria-labelledby=\"Bib1\" data-title=\"References\">\n<h2 id=\"Bib1\">References<\/h2>\n<div data-container-section=\"references\" id=\"Bib1-content\">\n<ol data-track-component=\"outbound reference\">\n<li data-counter=\"1.\">\n<p id=\"ref-CR1\">Arnold, F. 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Colwell<\/p>\n<\/li>\n<\/ol>\n<h3 id=\"corresponding-author\">Corresponding author<\/h3>\n<p id=\"corresponding-author-list\">Correspondence to<br \/>\n                <a id=\"corresp-c1\" href=\"http:\/\/www.nature.com\/mailto:lj***@****ac.uk\" data-original-string=\"5fspt0BOGqIgwWXtJUG1UQ==7f4BIX5zsoai1yo9kp34Ir2hg==\" title=\"This contact has been encoded by Anti-Spam by CleanTalk. Click to decode. To finish the decoding make sure that JavaScript is enabled in your browser.\">Lucy J. Colwell<\/a>.<\/p>\n<\/div>\n<\/div>\n<div id=\"ethics-section\" data-title=\"Ethics declarations\">\n<h2 id=\"ethics\">Ethics declarations<\/h2>\n<div id=\"ethics-content\">\n<h3 id=\"FPar1\">Competing interests<\/h3>\n<p>D.B. and L.J.C. have performed research as part of their employment at Google LLC. 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Hallucinating functional protein sequences.<br \/>\n                    <i>Nat Biotechnol<\/i>  (2023). https:\/\/doi.org\/10.1038\/s41587-022-01634-2<\/p>\n<p><a data-test=\"citation-link\" data-track=\"click\" data-track-action=\"download article citation\" data-track-label=\"link\" data-track-external rel=\"nofollow\" href=\"https:\/\/citation-needed.springer.com\/v2\/references\/10.1038\/s41587-022-01634-2?format=refman&#038;flavour=citation\">Download citation<\/a><\/p>\n<ul data-test=\"publication-history\">\n<li>\n<p>Published<span>: <\/span><span><time datetime=\"2023-01-26\">26 January 2023<\/time><\/span><\/p>\n<\/li>\n<li>\n<p><abbr title=\"Digital Object Identifier\">DOI<\/abbr><span>: <\/span><span>https:\/\/doi.org\/10.1038\/s41587-022-01634-2<\/span><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div><\/div>\n<\/p><\/div>\n<\/div>\n<section aria-label=\"CAS reference 1\"33 data-component-reading-companion data-container-type=\"reading-companion\" data-track-component=\"reading companion\">\n<h2>Associated Content<\/h2>\n<\/section>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41587-022-01634-2\" class=\"button purchase\" rel=\"nofollow noopener\" target=\"_blank\">Read More<\/a><br \/>\n David Belanger<\/p>\n","protected":false},"excerpt":{"rendered":"<p>News &amp; Views Published: 26 January 2023 Protein engineering Nature Biotechnology (2023)Cite this article 640 Accesses 7 Altmetric Metrics details Subjects Functional proteins with limited homology to natural proteins are designed using a large language model. Directed evolution has proven remarkably successful at finding variants of known proteins with enhanced properties1. Yet designing proteins that<\/p>\n","protected":false},"author":1,"featured_media":602606,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[38158,99055,536],"tags":[],"class_list":{"0":"post-602605","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-functional","8":"category-hallucinating","9":"category-science-nature"},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts\/602605","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/comments?post=602605"}],"version-history":[{"count":0,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts\/602605\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/media\/602606"}],"wp:attachment":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/media?parent=602605"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/categories?post=602605"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/tags?post=602605"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}