{"id":597169,"date":"2023-01-13T10:50:33","date_gmt":"2023-01-13T16:50:33","guid":{"rendered":"https:\/\/news.sellorbuyhomefast.com\/index.php\/2023\/01\/13\/scientists-find-way-to-heal-scars-left-behind-by-heart-attacks\/"},"modified":"2023-01-13T10:50:33","modified_gmt":"2023-01-13T16:50:33","slug":"scientists-find-way-to-heal-scars-left-behind-by-heart-attacks","status":"publish","type":"post","link":"https:\/\/newsycanuse.com\/index.php\/2023\/01\/13\/scientists-find-way-to-heal-scars-left-behind-by-heart-attacks\/","title":{"rendered":"Scientists find way to heal scars left behind by heart attacks"},"content":{"rendered":"<div>\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2023\/scientists-find-way-to.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2023\/scientists-find-way-to.jpg\" data-sub-html=\"Credit: <i>Circulation Research<\/i> (2022). DOI: 10.1161\/CIRCRESAHA.122.321123&#8243;><\/p>\n<figure>\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2023\/scientists-find-way-to.jpg\" alt=\"Scientists find way to heal scars left behind by heart attacks\" title=\"Credit:  Circulation Research  (2022). DOI: 10.1161\/CIRCRESAHA.122.321123\" width=\"800\" height=\"530\"><figcaption>\n                Credit: <i>Circulation Research<\/i> (2022). DOI: 10.1161\/CIRCRESAHA.122.321123<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<p>After a heart attack, the shock of the event leaves behind a trail of damaged heart muscle, which becomes a scar over time. However, the scar tissue doesn&#8217;t have the elasticity and flexibility of healthy heart muscle, meaning there can be complications with pumping and transporting blood.\n                                                <\/p>\n<p>For the first time, an international team of researchers has developed a method to reverse the loss of elasticity of damaged heart tissue following heart attacks.\n<\/p>\n<p>Heart disease is currently the largest cause of death globally.\n<\/p>\n<p>Preclinical studies in rats have found that a single injection of <a href=\"https:\/\/medicalxpress.com\/tags\/tropoelastin\/\" rel=\"tag\">tropoelastin<\/a> into the wall of the heart in the days following a heart attack could &#8220;turn back the clock&#8221; on muscle damage, making the <a href=\"https:\/\/medicalxpress.com\/tags\/scars\/\" rel=\"tag\">scars<\/a> &#8220;stretchier&#8221; and help improve the heart&#8217;s ability to contract. Tropoelastin is the protein building block that gives human tissue its elasticity and ability to stretch.\n<\/p>\n<p>The results are published in <i>Circulation Research<\/i> and represent the first time this potential of tropoelastin in treating heart disease has been investigated.\n<\/p>\n<p>&#8220;This research showcases the potential of tropoelastin in heart repair and suggest further work will show exciting possibilities of its role in future treatments and therapies,&#8221; says lead researcher Dr. Robert Hume, who conducted the research at the Westmead Institute for Medical Research. Dr. Hume is currently based at the University of Sydney&#8217;s Charles Perkins Centre.\n<\/p>\n<figure itemscope itemtype=\"http:\/\/schema.org\/VideoObject\">\n    <meta itemprop=\"name\" content=\"Scientists find way to heal scars left behind by heart attacks\"><br \/>\n    <meta itemprop=\"url\" content=\"https:\/\/www.youtube.com\/watch\/?v=fhzNR6yekA0\"><br \/>\n    <meta itemprop=\"description\" content=\"Scientists find way to heal scars left behind by heart attacks\"><br \/>\n    <meta itemprop=\"uploadDate\" content=\"2023-01-12T15:52:10-05:00\"><br \/>\n        <meta itemprop=\"embedUrl\" content=\"https:\/\/www.youtube.com\/embed\/fhzNR6yekA0\"><br \/>\n    <meta itemprop=\"thumbnailUrl\" content=\"https:\/\/img.youtube.com\/vi\/fhzNR6yekA0\/maxresdefault.jpg\"><\/p>\n<p>\n             <iframe src=\"https:\/\/www.youtube.com\/embed\/fhzNR6yekA0?color=white\" loading=\"lazy\" frameborder=\"0\" allowfullscreen><\/iframe>\n         <\/p>\n<\/figure>\n<p>Four days after a heart attack, purified tropoelastin was injected into the heart.\n<\/p>\n<p>Co-author Professor Anthony Weiss from the Charles Perkins Centre and Faculty of Science explained, &#8220;Tropoelastin can repair the heart because it is a precise replica of the body&#8217;s natural elastic protein.&#8221;\n<\/p>\n<p>For this injection, the researchers used a new surgical method utilizing ultrasound to guide the needle into the heart wall, which is less invasive than previous methods.\n<\/p>\n<p>After 28 days the researchers found the heart muscle, originally damaged and scarred at the beginning, had regained its elasticity and its muscle function resembled that before the <a href=\"https:\/\/medicalxpress.com\/tags\/heart+attack\/\" rel=\"tag\">heart attack<\/a>.\n<\/p>\n<p>Further tests found that tropoelastin reduces scar size and essentially stabilizes it by increasing its elastin content and therefore decreasing the stiffness of the scar.\n<\/p>\n<p>Additional experiments on human cardiac fibroblasts (a subset of human heart cells responsible for maintaining the structure of a normal heart) in a petri dish showed that after the cells were treated with tropoelastin, they were able to generate elastin, a crucial protein that gives human tissue elasticity and the ability to stretch.\n<\/p>\n<p>&#8220;What we have found is highly encouraging,&#8221; says senior author Associate Professor James Chong. &#8220;We hope to continue developing the method so it can eventually be used in a clinical setting and used to treat and improve the lives of the millions of heart failure patients worldwide.&#8221;<\/p>\n<div>\n<p>\n                                                        <strong>More information:<\/strong><br \/>\n                                                        Robert D. Hume et al, Tropoelastin Improves Post-Infarct Cardiac Function, <i>Circulation Research<\/i> (2022).  <a data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1161\/CIRCRESAHA.122.321123\" target=\"_blank\" rel=\"noopener\">DOI: 10.1161\/CIRCRESAHA.122.321123<\/a><\/p>\n<\/p><\/div>\n<div>\n<p><strong>Citation<\/strong>:<br \/>\n                                                 Scientists find way to heal scars left behind by heart attacks (2023, January 12)<br \/>\n                                                 retrieved 13 January 2023<br \/>\n                                                 from https:\/\/medicalxpress.com\/news\/2023-01-scientists-scars-left-heart.html\n                                            <\/p>\n<p>\n                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.\n                                            <\/p>\n<\/p><\/div>\n<\/p><\/div>\n<p><a href=\"https:\/\/medicalxpress.com\/news\/2023-01-scientists-scars-left-heart.html\" class=\"button purchase\" rel=\"nofollow noopener\" target=\"_blank\">Read More<\/a><br \/>\n Erasmo Ramage<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Credit: Circulation Research (2022). DOI: 10.1161\/CIRCRESAHA.122.321123 After a heart attack, the shock of the event leaves behind a trail of damaged heart muscle, which becomes a scar over time. However, the scar tissue doesn&#8217;t have the elasticity and flexibility of healthy heart muscle, meaning there can be complications with pumping and transporting blood. For the<\/p>\n","protected":false},"author":1,"featured_media":597170,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[36701,3807],"tags":[],"class_list":["post-597169","post","type-post","status-publish","format-standard","has-post-thumbnail","category-scars","category-scientists"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts\/597169","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/comments?post=597169"}],"version-history":[{"count":0,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts\/597169\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/media\/597170"}],"wp:attachment":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/media?parent=597169"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/categories?post=597169"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/tags?post=597169"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}