{"id":596849,"date":"2023-01-12T10:53:10","date_gmt":"2023-01-12T16:53:10","guid":{"rendered":"https:\/\/news.sellorbuyhomefast.com\/index.php\/2023\/01\/12\/protein-identification-using-a-digestion-free-nanopore-approach\/"},"modified":"2023-01-12T10:53:10","modified_gmt":"2023-01-12T16:53:10","slug":"protein-identification-using-a-digestion-free-nanopore-approach","status":"publish","type":"post","link":"https:\/\/newsycanuse.com\/index.php\/2023\/01\/12\/protein-identification-using-a-digestion-free-nanopore-approach\/","title":{"rendered":"Protein identification using a digestion-free nanopore approach"},"content":{"rendered":"<div>\n<header>\n<ul data-test=\"article-identifier\">\n<li data-test=\"article-category\">Research Briefing<\/li>\n<li><a href=\"http:\/\/www.nature.com\/#article-info\" data-track=\"click\" data-track-action=\"publication date\" data-track-label=\"link\">Published: <time datetime=\"2023-01-09\">09 January 2023<\/time><\/a><\/li>\n<\/ul>\n<ul data-test=\"authors-list\" data-component-authors-activator=\"authors-list\"><\/ul>\n<p data-container-section=\"info\">\n<p>    <a data-test=\"journal-link\" href=\"http:\/\/www.nature.com\/nbt\"><i data-test=\"journal-title\">Nature Biotechnology<\/i><\/a><\/p>\n<p>                         (<span data-test=\"article-publication-year\">2023<\/span>)<a href=\"http:\/\/www.nature.com\/#citeas\" data-track=\"click\" data-track-action=\"cite this article\" data-track-label=\"link\">Cite this article<\/a>\n                    <\/p>\n<div>\n<ul>\n<li>\n<p>330 <span>Accesses<\/span><\/p>\n<\/li>\n<li>\n<p>7 <span>Altmetric<\/span><\/p>\n<\/li>\n<li>\n<p><a href=\"http:\/\/www.nature.com\/articles\/s41587-022-01599-2\/metrics\" data-track=\"click\" data-track-action=\"view metrics\" data-track-label=\"link\" rel=\"nofollow\">Metrics <span>details<\/span><\/a><\/p>\n<\/li>\n<\/ul><\/div>\n<\/header>\n<div data-component=\"article-subject-links\">\n<h3>Subjects<\/h3>\n<\/p><\/div>\n<\/p><\/div>\n<div>\n<p>Sequencing of proteins is a technically difficult task that typically requires digestion into short peptides before detection and identification. We developed a digestion-free method to chemically unfold and \u2018scan\u2019 full-length proteins through a nanopore, producing electrical fingerprints unique to individual protein molecules that are useful in their identification.<\/p>\n<div>\n<p>This is a preview of subscription content, <a href=\"https:\/\/wayf.springernature.com?redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41587-022-01599-2\" data-track=\"click\" data-track-action=\"institution access preview subscription\" data-track-label=\"link\">access via your institution<\/a><\/p>\n<\/p><\/div>\n<h2 id=\"access-options\">Access options<\/h2>\n<section>\n<div>\n<p>Subscribe to Nature+<\/p>\n<p>Get immediate online access to Nature and 55 other Nature journal<\/p>\n<\/div>\n<div>\n<p>Subscribe to Journal<\/p>\n<p>Get full journal access for 1 year<\/p>\n<div>\n<p id=\"subscription-price\">$99.00<\/p>\n<p>only $8.25 per issue<\/p>\n<\/div>\n<p>All prices are NET prices.<br \/> VAT will be added later in the checkout.<br \/>Tax calculation will be finalised during checkout.<\/p>\n<\/div>\n<div>\n<p>Buy article<\/p>\n<p>Get time limited or full article access on ReadCube.<\/p>\n<p id=\"readcube-price\">$32.00<\/p>\n<p>All prices are NET prices.<\/p>\n<\/div>\n<\/section>\n<nav>\n<h3>Additional access options:<\/h3>\n<ul>\n<li>\n            <a href=\"https:\/\/idp.nature.com\/authorize\/natureuser?client_id=grover&#038;redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41587-022-01599-2\" data-track=\"click\" data-track-action=\"login\" data-track-category=\"article body\" data-track-label=\"link\">Log in<\/a>\n        <\/li>\n<li>\n            <a href=\"https:\/\/www.springernature.com\/gp\/librarians\/licensing\/license-options\" data-track=\"click\" data-track-action=\"learn-subscription\" data-track-category=\"article body\" data-track-label=\"link\">Learn about institutional subscriptions<\/a>\n        <\/li>\n<\/ul>\n<\/nav>\n<div data-test=\"figure\" data-container-section=\"figure\" id=\"figure-1\">\n<figure><figcaption><b id=\"Fig1\" data-test=\"figure-caption-text\">Fig. 1: Full-length protein transport through a nanopore.<\/b><\/figcaption><div><picture><source type=\"image\/webp\" ><img decoding=\"async\" src=\"http:\/\/media.springernature.com\/m312\/springer-static\/image\/art%3A10.1038%2Fs41587-022-01599-2\/MediaObjects\/41587_2022_1599_Fig1_HTML.png\" alt loading=\"lazy\" width=\"312\" height=\"228\"><\/picture><\/div>\n<\/figure>\n<\/div>\n<div>\n<div id=\"MagazineFulltextArticleBodySuffix\" aria-labelledby=\"Bib1\" data-title=\"References\">\n<h2 id=\"Bib1\">References<\/h2>\n<div data-container-section=\"references\" id=\"Bib1-content\">\n<ol data-track-component=\"outbound reference\">\n<li data-counter=\"1.\">\n<p id=\"ref-CR1\">Alfaro, J. 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Unidirectional single-file transport of full-length proteins through a nanopore. <i>Nat. Biotechnol<\/i>. <a href=\"https:\/\/doi.org\/10.1038\/s41587-022-01598-3\">https:\/\/doi.org\/10.1038\/s41587-022-01598-3<\/a> (2023)<\/p>\n<\/div>\n<\/div>\n<div id=\"rightslink-section\" data-title=\"Rights and permissions\">\n<h2 id=\"rightslink\">Rights and permissions<\/h2>\n<\/div>\n<div id=\"article-info-section\" aria-labelledby=\"article-info\" data-title=\"About this article\">\n<h2 id=\"article-info\">About this article<\/h2>\n<div id=\"article-info-content\">\n<p><a data-crossmark=\"10.1038\/s41587-022-01599-2\" target=\"_blank\" rel=\"noopener\" href=\"https:\/\/crossmark.crossref.org\/dialog\/?doi=10.1038\/s41587-022-01599-2\" data-track=\"click\" data-track-action=\"Click Crossmark\" data-track-label=\"link\" data-test=\"crossmark\"><img loading=\"lazy\" decoding=\"async\" width=\"57\" height=\"81\" alt=\"Verify currency and authenticity via CrossMark\" src=\"data:image\/svg+xml;base64,<svg height="81" width="57" xmlns="http://www.w3.org/2000/svg"><g fill="none" 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1.3zm3.01 2.23c.31.24.61.43.92.57.3.13.63.2.98.2.38 0 .65-.08.83-.23s.27-.35.27-.6c0-.14-.05-.26-.13-.37-.08-.1-.2-.2-.34-.28-.14-.09-.29-.16-.47-.23l-.53-.22c-.23-.09-.46-.18-.69-.3-.23-.11-.44-.24-.62-.4s-.33-.35-.45-.55c-.12-.21-.18-.46-.18-.75 0-.61.23-1.1.68-1.49.44-.38 1.06-.57 1.83-.57.48 0 .91.08 1.29.25s.71.36.99.57l-.74.98c-.24-.17-.49-.32-.73-.42-.25-.11-.51-.16-.78-.16-.35 0-.6.07-.76.21-.17.15-.25.33-.25.54 0 .14.04.26.12.36s.18.18.31.26c.14.07.29.14.46.21l.54.19c.23.09.47.18.7.29s.44.24.64.4c.19.16.34.35.46.58.11.23.17.5.17.82 0 .3-.06.58-.17.83-.12.26-.29.48-.51.68-.23.19-.51.34-.84.45-.34.11-.72.17-1.15.17-.48 0-.95-.09-1.41-.27-.46-.19-.86-.41-1.2-.68z" fill="#535353"/></g></svg>\"><\/a><\/p>\n<div>\n<h3 id=\"citeas\">Cite this article<\/h3>\n<p> Protein identification using a digestion-free nanopore approach.<br \/>\n                    <i>Nat Biotechnol<\/i>  (2023). https:\/\/doi.org\/10.1038\/s41587-022-01599-2<\/p>\n<p><a data-test=\"citation-link\" data-track=\"click\" data-track-action=\"download article citation\" data-track-label=\"link\" data-track-external rel=\"nofollow\" href=\"https:\/\/citation-needed.springer.com\/v2\/references\/10.1038\/s41587-022-01599-2?format=refman&#038;flavour=citation\">Download citation<\/a><\/p>\n<ul data-test=\"publication-history\">\n<li>\n<p>Published<span>: <\/span><span><time datetime=\"2023-01-09\">09 January 2023<\/time><\/span><\/p>\n<\/li>\n<li>\n<p><abbr title=\"Digital Object Identifier\">DOI<\/abbr><span>: <\/span><span>https:\/\/doi.org\/10.1038\/s41587-022-01599-2<\/span><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div><\/div>\n<\/p><\/div>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41587-022-01599-2\" class=\"button purchase\" rel=\"nofollow noopener\" target=\"_blank\">Read More<\/a><br \/>\n Tama Fleishman<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research Briefing Published: 09 January 2023 Nature Biotechnology (2023)Cite this article 330 Accesses 7 Altmetric Metrics details Subjects Sequencing of proteins is a technically difficult task that typically requires digestion into short peptides before detection and identification. We developed a digestion-free method to chemically unfold and \u2018scan\u2019 full-length proteins through a nanopore, producing electrical fingerprints<\/p>\n","protected":false},"author":1,"featured_media":596850,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[93999,25669,536],"tags":[],"class_list":{"0":"post-596849","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-identification","8":"category-protein","9":"category-science-nature"},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts\/596849","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/comments?post=596849"}],"version-history":[{"count":0,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts\/596849\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/media\/596850"}],"wp:attachment":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/media?parent=596849"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/categories?post=596849"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/tags?post=596849"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}