{"id":593924,"date":"2023-01-04T06:53:18","date_gmt":"2023-01-04T12:53:18","guid":{"rendered":"https:\/\/news.sellorbuyhomefast.com\/index.php\/2023\/01\/04\/writing-cellular-history-in-protein-chains\/"},"modified":"2023-01-04T06:53:18","modified_gmt":"2023-01-04T12:53:18","slug":"writing-cellular-history-in-protein-chains","status":"publish","type":"post","link":"https:\/\/newsycanuse.com\/index.php\/2023\/01\/04\/writing-cellular-history-in-protein-chains\/","title":{"rendered":"Writing cellular history in protein chains"},"content":{"rendered":"<div data-track-component=\"article body\">\n<article lang=\"en\">\n<div>\n<header>\n<ul data-test=\"article-identifier\">\n<li data-test=\"article-category\">News &#038; Views<\/li>\n<li><a href=\"http:\/\/www.nature.com\/#article-info\" data-track=\"click\" data-track-action=\"publication date\" data-track-label=\"link\">Published: <time datetime=\"2023-01-02\">02 January 2023<\/time><\/a><\/li>\n<\/ul>\n<p>Single-cell technology<\/p>\n<p data-container-section=\"info\">\n<p>    <a data-test=\"journal-link\" href=\"http:\/\/www.nature.com\/nbt\"><i data-test=\"journal-title\">Nature Biotechnology<\/i><\/a><\/p>\n<p>                         (<span data-test=\"article-publication-year\">2023<\/span>)<a href=\"http:\/\/www.nature.com\/#citeas\" data-track=\"click\" data-track-action=\"cite this article\" data-track-label=\"link\">Cite this article<\/a>\n                    <\/p>\n<div>\n<ul>\n<li>\n<p>180 <span>Accesses<\/span><\/p>\n<\/li>\n<li>\n<p>18 <span>Altmetric<\/span><\/p>\n<\/li>\n<li>\n<p><a href=\"http:\/\/www.nature.com\/articles\/s41587-022-01597-4\/metrics\" data-track=\"click\" data-track-action=\"view metrics\" data-track-label=\"link\" rel=\"nofollow\">Metrics <span>details<\/span><\/a><\/p>\n<\/li>\n<\/ul><\/div>\n<\/header>\n<div data-component=\"article-subject-links\">\n<h3>Subjects<\/h3>\n<\/p><\/div>\n<\/p><\/div>\n<div>\n<p>Elongating protein fibers record the transcriptional activity of single cells for later readout by imaging.<\/p>\n<p>Previous studies have demonstrated the feasibility of encoding cellular history in the form of nucleic acid. However, analysis of DNA or RNA sequence modifications requires cell lysis, which eliminates spatial information. In contrast, the protein-based methods of Lin et al. and Linghu et al. retain spatial information, enabling activity mapping in complex cellular populations in the context of intact tissues.<\/p>\n<div>\n<p>This is a preview of subscription content, <a href=\"https:\/\/wayf.springernature.com?redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41587-022-01597-4\" data-track=\"click\" data-track-action=\"institution access preview subscription\" data-track-label=\"link\">access via your institution<\/a><\/p>\n<\/p><\/div>\n<h2 id=\"access-options\">Access options<\/h2>\n<section>\n<div>\n<p>Subscribe to Nature+<\/p>\n<p>Get immediate online access to Nature and 55 other Nature journal<\/p>\n<\/div>\n<div>\n<p>Subscribe to Journal<\/p>\n<p>Get full journal access for 1 year<\/p>\n<div>\n<p id=\"subscription-price\">$99.00<\/p>\n<p>only $8.25 per issue<\/p>\n<\/div>\n<p>All prices are NET prices.<br \/> VAT will be added later in the checkout.<br \/>Tax calculation will be finalised during checkout.<\/p>\n<\/div>\n<div>\n<p>Buy article<\/p>\n<p>Get time limited or full article access on ReadCube.<\/p>\n<p id=\"readcube-price\">$32.00<\/p>\n<p>All prices are NET prices.<\/p>\n<\/div>\n<\/section>\n<nav>\n<h3>Additional access options:<\/h3>\n<ul>\n<li>\n            <a href=\"https:\/\/idp.nature.com\/authorize\/natureuser?client_id=grover&#038;redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41587-022-01597-4\" data-track=\"click\" data-track-action=\"login\" data-track-category=\"article body\" data-track-label=\"link\">Log in<\/a>\n        <\/li>\n<li>\n            <a href=\"https:\/\/www.springernature.com\/gp\/librarians\/licensing\/license-options\" data-track=\"click\" data-track-action=\"learn-subscription\" data-track-category=\"article body\" data-track-label=\"link\">Learn about institutional subscriptions<\/a>\n        <\/li>\n<\/ul>\n<\/nav>\n<div data-test=\"figure\" data-container-section=\"figure\" id=\"figure-1\">\n<figure><figcaption><b id=\"Fig1\" data-test=\"figure-caption-text\">Fig. 1: Molecular systems for recording transcriptional activity.<\/b><\/figcaption><div><picture><source type=\"image\/webp\" ><img decoding=\"async\" src=\"http:\/\/media.springernature.com\/m312\/springer-static\/image\/art%3A10.1038%2Fs41587-022-01597-4\/MediaObjects\/41587_2022_1597_Fig1_HTML.png\" alt loading=\"lazy\" width=\"312\" height=\"239\"><\/picture><\/div>\n<\/figure>\n<\/div>\n<div>\n<div id=\"MagazineFulltextArticleBodySuffix\" aria-labelledby=\"Bib1\" data-title=\"References\">\n<h2 id=\"Bib1\">References<\/h2>\n<div data-container-section=\"references\" id=\"Bib1-content\">\n<ol data-track-component=\"outbound reference\">\n<li data-counter=\"1.\">\n<p id=\"ref-CR1\">Chen, T. W. et al. <i>Nature<\/i> <b>499<\/b>, 295\u2013300 (2013).<\/p>\n<p><a data-track=\"click\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/nature12354\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fnature12354\" aria-label=\"Article reference 1\" data-doi=\"10.1038\/nature12354\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-action=\"cas reference\" href=\"http:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC3sXhtFalsrrI\" aria-label=\"CAS reference 1\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click\" data-track-action=\"google scholar reference\" data-track-label=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 1\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&#038;title=&#038;journal=Nature&#038;doi=10.1038%2Fnature12354&#038;volume=499&#038;pages=295-300&#038;publication_year=2013&#038;author=Chen%2CTW\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li data-counter=\"2.\">\n<p id=\"ref-CR2\">Park, Y. G. et al. <i>Nat. Biotechnol.<\/i> <a href=\"https:\/\/doi.org\/10.1038\/nbt.4281\">https:\/\/doi.org\/10.1038\/nbt.4281<\/a> (2018).<\/p>\n<p><a data-track=\"click\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/nbt.4281\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fnbt.4281\" aria-label=\"Article reference 2\" data-doi=\"10.1038\/nbt.4281\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click\" data-track-action=\"google scholar reference\" data-track-label=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 2\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&#038;title=&#038;journal=Nat.%20Biotechnol.&#038;doi=10.1038%2Fnbt.4281&#038;publication_year=2018&#038;author=Park%2CYG\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li data-counter=\"3.\">\n<p id=\"ref-CR3\">Renier, N. et al. <i>Cell<\/i> <b>165<\/b>, 1789\u20131802 (2016).<\/p>\n<p><a data-track=\"click\" rel=\"nofollow noopener\" data-track-label=\"10.1016\/j.cell.2016.05.007\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1016%2Fj.cell.2016.05.007\" aria-label=\"Article reference 3\" data-doi=\"10.1016\/j.cell.2016.05.007\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-action=\"cas reference\" href=\"http:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC28XptVSlsbY%3D\" aria-label=\"CAS reference 3\">CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click\" data-track-action=\"google scholar reference\" data-track-label=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 3\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&#038;title=&#038;journal=Cell&#038;doi=10.1016%2Fj.cell.2016.05.007&#038;volume=165&#038;pages=1789-1802&#038;publication_year=2016&#038;author=Renier%2CN\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li data-counter=\"4.\">\n<p id=\"ref-CR4\">Lin, D. et al. <i>Nat. Biotechnol.<\/i> <a href=\"https:\/\/doi.org\/10.1038\/s41587-022-01524-7\">https:\/\/doi.org\/10.1038\/s41587-022-01524-7<\/a> (2022).<\/p>\n<\/li>\n<li data-counter=\"5.\">\n<p id=\"ref-CR5\">Linghu, C. et al. <i>Nat. Biotechnol.<\/i> <a href=\"https:\/\/doi.org\/10.1038\/s41587-022-01586-7\">https:\/\/doi.org\/10.1038\/s41587-022-01586-7<\/a> (2022).<\/p>\n<p><a data-track=\"click\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/s41587-022-01586-7\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fs41587-022-01586-7\" aria-label=\"Article reference 5\" data-doi=\"10.1038\/s41587-022-01586-7\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click\" data-track-action=\"google scholar reference\" data-track-label=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 5\" href=\"http:\/\/scholar.google.com\/scholar_lookup?&#038;title=&#038;journal=Nat.%20Biotechnol.&#038;doi=10.1038%2Fs41587-022-01586-7&#038;publication_year=2022&#038;author=Linghu%2CC\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li data-counter=\"6.\">\n<p id=\"ref-CR6\">Baskaran, Y. et al. <i>Nat. Commun.<\/i> <b>6<\/b>, 8681 (2015).<\/p>\n<p><a data-track=\"click\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/ncomms9681\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fncomms9681\" aria-label=\"CAS reference 1\"00 data-doi=\"10.1038\/ncomms9681\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-action=\"cas reference\" href=\"http:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2MXhvFWlurvJ\" aria-label=\"CAS reference 1\"11>CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click\" data-track-action=\"google scholar reference\" data-track-label=\"link\" rel=\"nofollow noopener\" aria-label=\"CAS reference 1\"22 href=\"http:\/\/scholar.google.com\/scholar_lookup?&#038;title=&#038;journal=Nat.%20Commun.&#038;doi=10.1038%2Fncomms9681&#038;volume=6&#038;publication_year=2015&#038;author=Baskaran%2CY\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li data-counter=\"7.\">\n<p id=\"ref-CR7\">Garcia-Seisdedos, H., Empereur-Mot, C., Elad, N. &#038; Levy, E. D. <i>Nature<\/i> <b>548<\/b>, 244\u2013247 (2017).<\/p>\n<p><a data-track=\"click\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/nature23320\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fnature23320\" aria-label=\"CAS reference 1\"33 data-doi=\"10.1038\/nature23320\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-action=\"cas reference\" href=\"http:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2sXht1OjsrvM\" aria-label=\"CAS reference 1\"44>CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click\" data-track-action=\"google scholar reference\" data-track-label=\"link\" rel=\"nofollow noopener\" aria-label=\"CAS reference 1\"55 href=\"http:\/\/scholar.google.com\/scholar_lookup?&#038;title=&#038;journal=Nature&#038;doi=10.1038%2Fnature23320&#038;volume=548&#038;pages=244-247&#038;publication_year=2017&#038;author=Garcia-Seisdedos%2CH&#038;author=Empereur-Mot%2CC&#038;author=Elad%2CN&#038;author=Levy%2CED\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li data-counter=\"8.\">\n<p id=\"ref-CR8\">Lee, D., Hyun, J. H., Jung, K., Hannan, P. &#038; Kwon, H. B. <i>Nat. Biotechnol.<\/i> <b>35<\/b>, 858\u2013863 (2017).<\/p>\n<p><a data-track=\"click\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/nbt.3902\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fnbt.3902\" aria-label=\"CAS reference 1\"66 data-doi=\"10.1038\/nbt.3902\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-action=\"cas reference\" href=\"http:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2sXhtVOjsb%2FI\" aria-label=\"CAS reference 1\"77>CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click\" data-track-action=\"google scholar reference\" data-track-label=\"link\" rel=\"nofollow noopener\" aria-label=\"CAS reference 1\"88 href=\"http:\/\/scholar.google.com\/scholar_lookup?&#038;title=&#038;journal=Nat.%20Biotechnol.&#038;doi=10.1038%2Fnbt.3902&#038;volume=35&#038;pages=858-863&#038;publication_year=2017&#038;author=Lee%2CD&#038;author=Hyun%2CJH&#038;author=Jung%2CK&#038;author=Hannan%2CP&#038;author=Kwon%2CHB\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<li data-counter=\"9.\">\n<p id=\"ref-CR9\">Wang, W. et al. <i>Nat. Biotechnol.<\/i> <b>35<\/b>, 864\u2013871 (2017).<\/p>\n<p><a data-track=\"click\" rel=\"nofollow noopener\" data-track-label=\"10.1038\/nbt.3909\" data-track-action=\"article reference\" href=\"https:\/\/doi.org\/10.1038%2Fnbt.3909\" aria-label=\"CAS reference 1\"99 data-doi=\"10.1038\/nbt.3909\">Article<\/a>\u00a0<br \/>\n    <a data-track=\"click\" rel=\"nofollow noopener\" data-track-label=\"link\" data-track-action=\"cas reference\" href=\"http:\/\/www.nature.com\/articles\/cas-redirect\/1:CAS:528:DC%2BC2sXhtVOjsb%2FP\" aria-label=\"Google Scholar reference 1\"00>CAS<\/a>\u00a0<br \/>\n    <a data-track=\"click\" data-track-action=\"google scholar reference\" data-track-label=\"link\" rel=\"nofollow noopener\" aria-label=\"Google Scholar reference 1\"11 href=\"http:\/\/scholar.google.com\/scholar_lookup?&#038;title=&#038;journal=Nat.%20Biotechnol.&#038;doi=10.1038%2Fnbt.3909&#038;volume=35&#038;pages=864-871&#038;publication_year=2017&#038;author=Wang%2CW\"><br \/>\n                    Google Scholar<\/a>\u00a0\n                <\/p>\n<\/li>\n<\/ol>\n<p><a data-track=\"click\" data-track-action=\"download citation references\" data-track-label=\"link\" rel=\"nofollow\" href=\"https:\/\/citation-needed.springer.com\/v2\/references\/10.1038\/s41587-022-01597-4?format=refman&#038;flavour=references\">Download references<\/a><\/p>\n<\/div>\n<\/div>\n<div id=\"author-information-section\" aria-labelledby=\"author-information\" data-title=\"Author information\">\n<h2 id=\"author-information\">Author information<\/h2>\n<div id=\"author-information-content\">\n<h3 id=\"affiliations\">Authors and Affiliations<\/h3>\n<ol>\n<li id=\"Aff1\">\n<p>Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA<\/p>\n<p>Hyung-Bae Kwon<\/p>\n<\/li>\n<\/ol>\n<h3 id=\"corresponding-author\">Corresponding author<\/h3>\n<p id=\"corresponding-author-list\">Correspondence to<br \/>\n                <a id=\"corresp-c1\" href=\"http:\/\/www.nature.com\/mailto:hk*****@**mi.edu\" data-original-string=\"LZpJtX0pdFyGG34XYomg6g==7f4Ik2f\/DzMLKzH33zgpZK41Ah1mlsXeNTLGGdQ0BoVwgo=\" title=\"This contact has been encoded by Anti-Spam by CleanTalk. Click to decode. To finish the decoding make sure that JavaScript is enabled in your browser.\">Hyung-Bae Kwon<\/a>.<\/p>\n<\/div>\n<\/div>\n<div id=\"ethics-section\" data-title=\"Ethics declarations\">\n<h2 id=\"ethics\">Ethics declarations<\/h2>\n<div id=\"ethics-content\">\n<h3 id=\"FPar1\">Competing interests<\/h3>\n<p>The author declares no competing interests.<\/p>\n<\/p><\/div>\n<\/div>\n<div id=\"rightslink-section\" data-title=\"Rights and permissions\">\n<h2 id=\"rightslink\">Rights and permissions<\/h2>\n<\/div>\n<div id=\"article-info-section\" aria-labelledby=\"article-info\" data-title=\"About this article\">\n<h2 id=\"article-info\">About this article<\/h2>\n<div id=\"article-info-content\">\n<p><a data-crossmark=\"10.1038\/s41587-022-01597-4\" target=\"_blank\" rel=\"noopener\" href=\"https:\/\/crossmark.crossref.org\/dialog\/?doi=10.1038\/s41587-022-01597-4\" data-track=\"click\" data-track-action=\"Click Crossmark\" data-track-label=\"link\" data-test=\"crossmark\"><img 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0-.92-.08-1.33-.25-.41-.16-.77-.4-1.08-.7-.3-.31-.54-.69-.72-1.13-.17-.44-.26-.95-.26-1.52zm4.61-.62c0-.55-.11-.98-.34-1.28-.23-.31-.58-.47-1.06-.47-.41 0-.77.15-1.08.45-.31.29-.5.73-.57 1.3zm3.01 2.23c.31.24.61.43.92.57.3.13.63.2.98.2.38 0 .65-.08.83-.23s.27-.35.27-.6c0-.14-.05-.26-.13-.37-.08-.1-.2-.2-.34-.28-.14-.09-.29-.16-.47-.23l-.53-.22c-.23-.09-.46-.18-.69-.3-.23-.11-.44-.24-.62-.4s-.33-.35-.45-.55c-.12-.21-.18-.46-.18-.75 0-.61.23-1.1.68-1.49.44-.38 1.06-.57 1.83-.57.48 0 .91.08 1.29.25s.71.36.99.57l-.74.98c-.24-.17-.49-.32-.73-.42-.25-.11-.51-.16-.78-.16-.35 0-.6.07-.76.21-.17.15-.25.33-.25.54 0 .14.04.26.12.36s.18.18.31.26c.14.07.29.14.46.21l.54.19c.23.09.47.18.7.29s.44.24.64.4c.19.16.34.35.46.58.11.23.17.5.17.82 0 .3-.06.58-.17.83-.12.26-.29.48-.51.68-.23.19-.51.34-.84.45-.34.11-.72.17-1.15.17-.48 0-.95-.09-1.41-.27-.46-.19-.86-.41-1.2-.68z" fill="#535353"/></g></svg>\"><\/a><\/p>\n<div>\n<h3 id=\"citeas\">Cite this article<\/h3>\n<p>Kwon, HB. Writing cellular history in protein chains.<br \/>\n                    <i>Nat Biotechnol<\/i>  (2023). https:\/\/doi.org\/10.1038\/s41587-022-01597-4<\/p>\n<p><a data-test=\"citation-link\" data-track=\"click\" data-track-action=\"download article citation\" data-track-label=\"link\" data-track-external rel=\"nofollow\" href=\"https:\/\/citation-needed.springer.com\/v2\/references\/10.1038\/s41587-022-01597-4?format=refman&#038;flavour=citation\">Download citation<\/a><\/p>\n<ul data-test=\"publication-history\">\n<li>\n<p>Published<span>: <\/span><span><time datetime=\"2023-01-02\">02 January 2023<\/time><\/span><\/p>\n<\/li>\n<li>\n<p><abbr title=\"Digital Object Identifier\">DOI<\/abbr><span>: <\/span><span>https:\/\/doi.org\/10.1038\/s41587-022-01597-4<\/span><\/p>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div><\/div>\n<\/p><\/div>\n<\/div>\n<section aria-label=\"Google Scholar reference 1\"22 data-component-reading-companion data-container-type=\"reading-companion\" data-track-component=\"reading companion\">\n<h2>Associated Content<\/h2>\n<\/section>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41587-022-01597-4\" class=\"button purchase\" rel=\"nofollow noopener\" target=\"_blank\">Read More<\/a><br \/>\n Hyung-Bae Kwon<\/p>\n","protected":false},"excerpt":{"rendered":"<p>News &amp; Views Published: 02 January 2023 Single-cell technology Nature Biotechnology (2023)Cite this article 180 Accesses 18 Altmetric Metrics details Subjects Elongating protein fibers record the transcriptional activity of single cells for later readout by imaging. Previous studies have demonstrated the feasibility of encoding cellular history in the form of nucleic acid. However, analysis of<\/p>\n","protected":false},"author":1,"featured_media":593925,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[41722,536,26865],"tags":[],"class_list":{"0":"post-593924","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-cellular","8":"category-science-nature","9":"category-writing"},"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts\/593924","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/comments?post=593924"}],"version-history":[{"count":0,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/posts\/593924\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/media\/593925"}],"wp:attachment":[{"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/media?parent=593924"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/categories?post=593924"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsycanuse.com\/index.php\/wp-json\/wp\/v2\/tags?post=593924"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}