The co-inventor of Apple’s FaceID and Vision Pro technology has spent the past six years building a frontier artificial intelligence model that could one day help decode electrical activity in the brain to diagnose cognitive disorders.
Now Gidi Littwin’s startup, Hemispheric, has raised $52 million in funding after gathering data on 100,000 people’s brains to train deep-learning models to examine the brain without the need for invasive procedures.
Littwin left Apple in 2020, looking for a change. He found it when his Hemispheric cofounder, Hagai Lalazar, cold-messaged him on LinkedIn. Lalazar had begun to develop artificial intelligence to study the brain without the need for surgery, and was looking for a commercially minded cofounder to drive the company forward. By the time he found Littwin, he had spoken to around 75 candidates.
Littwin had helped develop FaceID, and at that time was working on hand-tracking for an augmented reality product, the Vision Pro. As part of this, he had to collect what he told WIRED were “hundreds of thousands of subjects’ worth of data” to train the deep learning models powering the technology.
“There were massive data collection operations behind these projects, and we knew we had to build something very similar at Hemispheric,” Littwin says, “and we have.”
Because each individual’s brain activity looks different, doctors have largely had to rely on subjective questionnaires and behavioral observations to diagnose depression, Alzheimer’s, and Parkinson’s. To get around that, Littwin and Lalazar collected their “most prized possession”: a quarter of a million hours of brain data from 100,000 paid volunteers across Asia, as well as in Tel Aviv and Boston. Subjects undertook a series of activities that looked like games but activated different parts of their brains.
That data helped train a frontier model, which infers brain function from electrical activity within the skull in the same way that large language models deduce meaning by statistically analyzing text. They then tested the generalized model on subsets of people, including those diagnosed with PTSD, schizophrenia, and depression, and said the model made accurate deductions about the individuals’ brain health. The team is currently working on a clinical study to test whether its model can diagnose and even predict Alzheimer’s.
Littwin and Lalazar will submit their first product, which will be used to study PTSD, to the FDA for approval early next year. They hope that will allow them to roll out the product to the public later in 2027.
To help diagnose a cognitive disorder, a patient wears a lightweight EEG headset that measures electrical activity in the brain for around 15 minutes while interacting with an app on a tablet. Hemispheric says its AI model will then help clinicians decode the signals to make diagnoses, select the most effective intervention by making predictions about treatment, and monitor progress.
“The future that we envision is one where this is akin to a blood test,” Lalazar says. “The device is going to be very, very cheap; it will be able to be sold and distributed throughout mental health clinics, hospitals, and even psychologists’ offices.”
AI-assisted diagnostic tools for conditions like lung cancer are already in clinical use and speeding up access to treatment across Europe. Meanwhile, AI giants, including OpenAI and Anthropic, are expanding into health care, intensifying competition for the raft of startups in the space.
Hemispheric has raised early-stage funding from American and Israeli venture capital firms and individual investors, including early Uber-backer Howard Morgan. It will use the money to advance partnerships with governments, health care organizations, and pharmaceutical firms, to hire more in the US, and work toward regulatory approval. It also plans to measure more brain data from millions of people in an effort to improve its model
The team is also developing its own brain scanners to obtain information that the company believes can provide more useful data for its models than traditional EEGs. “These devices were never built for machine learning and definitely not deep learning,” Littwin says.
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Isabella Ward