
A large clinical trial suggests vitamin D may slow biological aging by preserving telomeres.
Findings from the VITAL randomized controlled trial show that vitamin D supplementation can help preserve telomeres, the protective caps at the ends of chromosomes. These structures naturally shorten with age, a process linked to the onset of many health conditions.
The study, published in The A few short-term, small-scale studies have suggested that vitamin D or omega 3 fatty 
Reference: “Vitamin D3 and marine ω-3 fatty acids supplementation and leukocyte telomere length: 4-year findings from the VITamin D and OmegA-3 TriaL (VITAL) randomized controlled trial” by Haidong Zhu, JoAnn E Manson, Nancy R Cook, Bayu B Bekele, Li Chen, Kevin J Kane, Ying Huang, Wenjun Li, William Christen, I-Min Lee and Yanbin Dong, 21 May 2025, The American Journal of Clinical Nutrition.
DOI: 10.1016/j.ajcnut.2025.05.003
This work was supported by the National Heart, Lung and Blood Institute (R01 HL131674-01). The parent VITAL trial is supported by R01 AT011729.
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