Groundbreaking Study Reveals That Vitamin D May Slow Biological Aging

Doctor Holding Vitamin Supplement Medicine Capsule
A major clinical trial has uncovered compelling evidence that vitamin D supplementation helps preserve telomeres, the DNA structures that protect chromosomes and shorten with age. Credit: Shutterstock

A large clinical trial suggests vitamin D may slow biological aging by preserving telomeres.

Findings from the VITAL randomized controlled trial show that vitamin D supplementation can help preserve telomeres, the protective caps at the ends of chromosomes. These structures naturally shorten with age, a process linked to the onset of many health conditions.

The study, published in The JoAnn Manson and Faculty

JoAnn Manson, MD, and other VITAL faculty and staff at a research team meeting at BWH. Credit: JoAnn Manson, Brigham and Women’s Hospital

A few short-term, small-scale studies have suggested that vitamin D or omega 3 fatty

Reference: “Vitamin D3 and marine ω-3 fatty acids supplementation and leukocyte telomere length: 4-year findings from the VITamin D and OmegA-3 TriaL (VITAL) randomized controlled trial” by Haidong Zhu, JoAnn E Manson, Nancy R Cook, Bayu B Bekele, Li Chen, Kevin J Kane, Ying Huang, Wenjun Li, William Christen, I-Min Lee and Yanbin Dong, 21 May 2025, The American Journal of Clinical Nutrition.
DOI: 10.1016/j.ajcnut.2025.05.003

This work was supported by the National Heart, Lung and Blood Institute (R01 HL131674-01). The parent VITAL trial is supported by R01 AT011729.

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