Science & Nature
Recoded genomes could mitigate bacteriophage infections in cell cultures that produce biologic agents and reduce the likelihood of undesired horizontal gene transfer events. A study in Nature by Nyerges et al. generated new phage-resistant Escherichia coli strains that are engineered for dependence on a synthetic amino acid, thus nullifying their selective advantage in the absence of specific growth conditions.
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Fudge, J.B. Retrofitted E. coli genome confers phage resistance.
Nat Biotechnol 41, 470 (2023). https://doi.org/10.1038/s41587-023-01764-1
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DOI: https://doi.org/10.1038/s41587-023-01764-1
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Jared B. Fudge