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We present the Schmidt objective, a novel astronomy-inspired concept for designing multi-immersion microscope objectives with high numerical aperture, long working distance and large field of view. The Schmidt objective uses a spherical mirror and a correction plate to focus light. It is well suited for high-resolution imaging deep inside cleared biological samples.
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References
Richardson, D. S. et al. Tissue clearing. Nat Rev. Methods Primers 1, 84 (2021). This review article presents an overview of tissue clearing.
Zhao, S. et al. Cellular and molecular probing of intact human organs. Cell. 180, 796–812.e19 (2020). This paper reports SHANEL, a method to clear and stain entire human organs.
Schmidt, B. Ein lichtstarkes komafreies Spiegelsystem. Zentral-Zeitung für Optik und Mechanik 52(Heft 2), 25–26 (1931). This paper is describes the Schmidt telescope, invented in 1930 by the Estonian-born optician and astronomer Bernhard Schmidt (1879–1935).
McConnell, G. et al. A novel optical microscope for imaging large embryos and tissue volumes with sub-cellular resolution throughout. eLife 5, e18659 (2016). This paper introduces the Mesolens, a microscope objective with a massively increased field of view.
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This is a summary of: Voigt, F. F. et al. Reflective multi-immersion microscope objectives inspired by the Schmidt telescope. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-01717-8 (2023).
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Imaging the biological microcosmos with a tiny telescope.
Nat Biotechnol (2023). https://doi.org/10.1038/s41587-023-01740-9
Published:
DOI: https://doi.org/10.1038/s41587-023-01740-9
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Tami Michaud